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RRP1B

GENERAL INFORMATION

Gene name

 RRP1B

Gene description

 Ribosomal RNA processing 1B

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Ubiquitous nuclear expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Supported based on 2 antibodies.
HPA017893 , HPA020324
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA017893
HPA020324

GENE INFORMATION

Gene name

 RRP1B (HGNC Symbol)

Synonyms

 KIAA0179, Nnp1, PPP1R136, RRP1

Description

 Ribosomal RNA processing 1B (HGNC Symbol)

Entrez gene summary

Chromosome

 21

Cytoband

 q22.3

Chromosome location (bp)

 43659548 - 43696079

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000160208 (version 83.38)

Entrez gene

 23076

UniProt

 Q14684 (UniProt - Evidence at protein level)

neXtProt

 NX_Q14684

Antibodypedia

 RRP1B antibodies

PROTEIN BROWSER
RRP1B-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
RRP1B-001
ENSP00000339145
ENST00000340648
Q14684 [Direct mapping]
Ribosomal RNA processing protein 1 homolog B
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Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000791 [euchromatin]
GO:0000792 [heterochromatin]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0005829 [cytosol]
GO:0006364 [rRNA processing]
GO:0010923 [negative regulation of phosphatase activity]
GO:0030688 [preribosome, small subunit precursor]
GO:0044822 [poly(A) RNA binding]
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 758 aa
84.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.