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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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PCNT
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    TISSUE

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    CELL

  • PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

PCNT

Gene description

Pericentrin

Protein class

Disease related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in most cell types.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining consistent with RNA expression data.

Reliability score

Supported based on 2 antibodies.
HPA016820 , HPA019887
SHOW MORE

PROGNOSTIC SUMMARY

Gene product is not prognostic.
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY

HPA016820
HPA019887

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Most malignancies displayed weak to moderate, dot like, cytoplasmic positivity.

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Malignant cells generally displayed weak to moderate, often dot-like, cytoplasmic immunoreactivity.

GENE INFORMATION

Gene name

PCNT (HGNC Symbol)

Synonyms

KEN, KIAA0402, PCN, PCNT2, PCNTB, SCKL4

Description

Pericentrin (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene binds to calmodulin and is expressed in the centrosome. It is an integral component of the pericentriolar material (PCM). The protein contains a series of coiled-coil domains and a highly conserved PCM targeting motif called the PACT domain near its C-terminus. The protein interacts with the microtubule nucleation component gamma-tubulin and is likely important to normal functioning of the centrosomes, cytoskeleton, and cell-cycle progression. Mutations in this gene cause Seckel syndrome-4 and microcephalic osteodysplastic primordial dwarfism type II. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015]

Chromosome

21

Cytoband

q22.3

Chromosome location (bp)

46324122 - 46445769

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000160299 (version 83.38)

Entrez gene

5116

UniProt

O95613 (UniProt - Evidence at protein level)

neXtProt

NX_O95613

Antibodypedia

PCNT antibodies

PROTEIN BROWSER

PCNT-001
PCNT-007

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PCNT-001
ENSP00000352572
ENST00000359568
O95613 [Direct mapping]
Pericentrin
Show all
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000226 [microtubule cytoskeleton organization]
GO:0000242 [pericentriolar material]
GO:0000278 [mitotic cell cycle]
GO:0001701 [in utero embryonic development]
GO:0001764 [neuron migration]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005737 [cytoplasm]
GO:0005801 [cis-Golgi network]
GO:0005813 [centrosome]
GO:0005814 [centriole]
GO:0005815 [microtubule organizing center]
GO:0005829 [cytosol]
GO:0005874 [microtubule]
GO:0006996 [organelle organization]
GO:0007051 [spindle organization]
GO:0016020 [membrane]
GO:0021696 [cerebellar cortex morphogenesis]
GO:0021772 [olfactory bulb development]
GO:0031514 [motile cilium]
GO:0034451 [centriolar satellite]
GO:0035108 [limb morphogenesis]
GO:0035264 [multicellular organism growth]
GO:0036064 [ciliary basal body]
GO:0042384 [cilium assembly]
GO:0043066 [negative regulation of apoptotic process]
GO:0045171 [intercellular bridge]
GO:0048854 [brain morphogenesis]
GO:0061351 [neural precursor cell proliferation]
GO:0090316 [positive regulation of intracellular protein transport]
Show all
3336 aa
378 kDa
No 0
PCNT-007
ENSP00000404708
ENST00000418394
H7C2A3 [Direct mapping]
Pericentrin
Show all
   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
228 aa
25.8 kDa
No 0

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