Most breast cancers, hepatocellular carcinomas and gliomas as well as several malignant melanomas and renal cancers exhibited moderate to strong cytoplasmic positivity. Remaining cancer tissues were mainly negative.
ADAM metallopeptidase with thrombospondin type 1 motif, 13 (HGNC Symbol)
Entrez gene summary
This gene encodes a member of a family of proteins containing several distinct regions, including a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. The enzyme encoded by this gene specifically cleaves von Willebrand Factor (vWF). Defects in this gene are associated with thrombotic thrombocytopenic purpura. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]