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ADAMTS13

GENERAL INFORMATION

Gene name

 ADAMTS13

Gene description

 ADAM metallopeptidase with thrombospondin type 1 motif, 13

Protein class

 Disease related genes
Enzymes
Plasma proteins
Potential drug targets
Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Secreted

Number of transcripts

 6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Mixed
HPA (cell line):Mixed
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in several different tissue types, most abundant in liver.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Caution, Splice and/or transcript discrepancy exists.

Reliability score

 Uncertain based on 2 antibodies.
HPA042014 , HPA042844
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA042014
HPA042844

GENE INFORMATION

Gene name

 ADAMTS13 (HGNC Symbol)

Synonyms

 C9orf8, DKFZp434C2322, FLJ42993, MGC118899, MGC118900, TTP, vWF-CP, VWFCP

Description

 ADAM metallopeptidase with thrombospondin type 1 motif, 13 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of a family of proteins containing several distinct regions, including a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. The enzyme encoded by this gene specifically cleaves von Willebrand Factor (vWF). Defects in this gene are associated with thrombotic thrombocytopenic purpura. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

Chromosome

 9

Cytoband

 q34.2

Chromosome location (bp)

 133414358 - 133459402

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000160323 (version 83.38)

Entrez gene

 11093

UniProt

 Q76LX8 (UniProt - Evidence at protein level)

neXtProt

 NX_Q76LX8

Antibodypedia

 ADAMTS13 antibodies

PROTEIN BROWSER
ADAMTS13-001
ADAMTS13-002
ADAMTS13-003
ADAMTS13-006
ADAMTS13-201
ADAMTS13-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ADAMTS13-001
ENSP00000360997
ENST00000371929
Q76LX8 [Direct mapping]
A disintegrin and metalloproteinase with thrombospondin motifs 13
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Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Metallopeptidases
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004175 [endopeptidase activity]
GO:0004222 [metalloendopeptidase activity]
GO:0005178 [integrin binding]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005578 [proteinaceous extracellular matrix]
GO:0005615 [extracellular space]
GO:0005788 [endoplasmic reticulum lumen]
GO:0006493 [protein O-linked glycosylation]
GO:0006508 [proteolysis]
GO:0007160 [cell-matrix adhesion]
GO:0007229 [integrin-mediated signaling pathway]
GO:0008233 [peptidase activity]
GO:0008237 [metallopeptidase activity]
GO:0008270 [zinc ion binding]
GO:0009100 [glycoprotein metabolic process]
GO:0009636 [response to toxic substance]
GO:0009986 [cell surface]
GO:0016485 [protein processing]
GO:0030168 [platelet activation]
GO:0034341 [response to interferon-gamma]
GO:0034612 [response to tumor necrosis factor]
GO:0036066 [protein O-linked fucosylation]
GO:0043171 [peptide catabolic process]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0070670 [response to interleukin-4]
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 1427 aa
153.6 kDa 		Yes 0
ADAMTS13-002
ENSP00000347927
ENST00000355699
Q76LX8 [Direct mapping]
A disintegrin and metalloproteinase with thrombospondin motifs 13
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Metallopeptidases
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004222 [metalloendopeptidase activity]
GO:0005178 [integrin binding]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005578 [proteinaceous extracellular matrix]
GO:0005788 [endoplasmic reticulum lumen]
GO:0006493 [protein O-linked glycosylation]
GO:0006508 [proteolysis]
GO:0007160 [cell-matrix adhesion]
GO:0007229 [integrin-mediated signaling pathway]
GO:0008237 [metallopeptidase activity]
GO:0008270 [zinc ion binding]
GO:0009100 [glycoprotein metabolic process]
GO:0009986 [cell surface]
GO:0016485 [protein processing]
GO:0030168 [platelet activation]
GO:0036066 [protein O-linked fucosylation]
GO:0043171 [peptide catabolic process]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
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 1371 aa
147.8 kDa 		Yes 0
ADAMTS13-003
ENSP00000348997
ENST00000356589
Q76LX8 [Direct mapping]
A disintegrin and metalloproteinase with thrombospondin motifs 13
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Metallopeptidases
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004222 [metalloendopeptidase activity]
GO:0005178 [integrin binding]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005578 [proteinaceous extracellular matrix]
GO:0005788 [endoplasmic reticulum lumen]
GO:0006493 [protein O-linked glycosylation]
GO:0006508 [proteolysis]
GO:0007160 [cell-matrix adhesion]
GO:0007229 [integrin-mediated signaling pathway]
GO:0008237 [metallopeptidase activity]
GO:0008270 [zinc ion binding]
GO:0009100 [glycoprotein metabolic process]
GO:0009986 [cell surface]
GO:0016485 [protein processing]
GO:0030168 [platelet activation]
GO:0036066 [protein O-linked fucosylation]
GO:0043171 [peptide catabolic process]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
Show all
 1340 aa
144.5 kDa 		Yes 0
ADAMTS13-006
ENSP00000360978
ENST00000371910
A0A0C4DFV8 [Direct mapping]
A disintegrin and metalloproteinase with thrombospondin motifs 13
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 223 aa
24.5 kDa 		No 0
ADAMTS13-201
ENSP00000360979
ENST00000371911
A0A0B4J229 [Direct mapping]
A disintegrin and metalloproteinase with thrombospondin motifs 13
Show all
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004222 [metalloendopeptidase activity]
GO:0006508 [proteolysis]
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 344 aa
36.7 kDa 		Yes 0
ADAMTS13-202
ENSP00000360984
ENST00000371916
E7EV88 [Direct mapping]
A disintegrin and metalloproteinase with thrombospondin motifs 13
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004222 [metalloendopeptidase activity]
GO:0005578 [proteinaceous extracellular matrix]
GO:0006508 [proteolysis]
GO:0008270 [zinc ion binding]
Show all
 444 aa
48.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.