Tissue expression of ADAMTS13 - Summary - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

ADAMTS13

TISSUE

CELL

PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	ADAMTS13
Gene description	ADAM metallopeptidase with thrombospondin type 1 motif, 13
Protein class	Disease related genes Enzymes Plasma proteins Potential drug targets Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	6
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Mixed
GTEx:	Expressed in all
FANTOM5:	Tissue enriched (liver)

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic expression in several different tissue types, most abundant in liver.

DATA RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Caution, Splice and/or transcript discrepancy exists.
Reliability score	Uncertain based on 2 antibodies. HPA042014 , HPA042844
	SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Mixed
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (liver)

GENE INFORMATION
Gene name	ADAMTS13 (HGNC Symbol)
Synonyms	C9orf8, DKFZp434C2322, FLJ42993, MGC118899, MGC118900, TTP, vWF-CP, VWFCP
Description	ADAM metallopeptidase with thrombospondin type 1 motif, 13 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of a family of proteins containing several distinct regions, including a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. The enzyme encoded by this gene specifically cleaves von Willebrand Factor (vWF). Defects in this gene are associated with thrombotic thrombocytopenic purpura. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Chromosome	9
Cytoband	q34.2
Chromosome location (bp)	133414358 - 133459402
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000160323 (version 83.38)
Entrez gene	11093
UniProt	Q76LX8 (UniProt - Evidence at protein level)
neXtProt	NX_Q76LX8
Antibodypedia	ADAMTS13 antibodies

PROTEIN BROWSER

ADAMTS13-001	ADAMTS13-002	ADAMTS13-003	ADAMTS13-006	ADAMTS13-201	ADAMTS13-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ADAMTS13-001 ENSP00000360997 ENST00000371929	Q76LX8 [Direct mapping] A disintegrin and metalloproteinase with thrombospondin motifs 13 Show all	Enzymes ENZYME proteins Hydrolases Peptidases Metallopeptidases THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0004175 [endopeptidase activity] GO:0004222 [metalloendopeptidase activity] GO:0005178 [integrin binding] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005578 [proteinaceous extracellular matrix] GO:0005615 [extracellular space] GO:0005788 [endoplasmic reticulum lumen] GO:0006493 [protein O-linked glycosylation] GO:0006508 [proteolysis] GO:0007160 [cell-matrix adhesion] GO:0007229 [integrin-mediated signaling pathway] GO:0008233 [peptidase activity] GO:0008237 [metallopeptidase activity] GO:0008270 [zinc ion binding] GO:0009100 [glycoprotein metabolic process] GO:0009636 [response to toxic substance] GO:0009986 [cell surface] GO:0016485 [protein processing] GO:0030168 [platelet activation] GO:0034341 [response to interferon-gamma] GO:0034612 [response to tumor necrosis factor] GO:0036066 [protein O-linked fucosylation] GO:0043171 [peptide catabolic process] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0070670 [response to interleukin-4] Show all	1427 aa 153.6 kDa	Yes	0
ADAMTS13-002 ENSP00000347927 ENST00000355699	Q76LX8 [Direct mapping] A disintegrin and metalloproteinase with thrombospondin motifs 13 Show all	Enzymes ENZYME proteins Hydrolases Peptidases Metallopeptidases THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0004222 [metalloendopeptidase activity] GO:0005178 [integrin binding] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005578 [proteinaceous extracellular matrix] GO:0005788 [endoplasmic reticulum lumen] GO:0006493 [protein O-linked glycosylation] GO:0006508 [proteolysis] GO:0007160 [cell-matrix adhesion] GO:0007229 [integrin-mediated signaling pathway] GO:0008237 [metallopeptidase activity] GO:0008270 [zinc ion binding] GO:0009100 [glycoprotein metabolic process] GO:0009986 [cell surface] GO:0016485 [protein processing] GO:0030168 [platelet activation] GO:0036066 [protein O-linked fucosylation] GO:0043171 [peptide catabolic process] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] Show all	1371 aa 147.8 kDa	Yes	0
ADAMTS13-003 ENSP00000348997 ENST00000356589	Q76LX8 [Direct mapping] A disintegrin and metalloproteinase with thrombospondin motifs 13 Show all	Enzymes ENZYME proteins Hydrolases Peptidases Metallopeptidases THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0004222 [metalloendopeptidase activity] GO:0005178 [integrin binding] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005578 [proteinaceous extracellular matrix] GO:0005788 [endoplasmic reticulum lumen] GO:0006493 [protein O-linked glycosylation] GO:0006508 [proteolysis] GO:0007160 [cell-matrix adhesion] GO:0007229 [integrin-mediated signaling pathway] GO:0008237 [metallopeptidase activity] GO:0008270 [zinc ion binding] GO:0009100 [glycoprotein metabolic process] GO:0009986 [cell surface] GO:0016485 [protein processing] GO:0030168 [platelet activation] GO:0036066 [protein O-linked fucosylation] GO:0043171 [peptide catabolic process] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] Show all	1340 aa 144.5 kDa	Yes	0
ADAMTS13-006 ENSP00000360978 ENST00000371910	A0A0C4DFV8 [Direct mapping] A disintegrin and metalloproteinase with thrombospondin motifs 13 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		223 aa 24.5 kDa	No	0
ADAMTS13-201 ENSP00000360979 ENST00000371911	A0A0B4J229 [Direct mapping] A disintegrin and metalloproteinase with thrombospondin motifs 13 Show all	THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004222 [metalloendopeptidase activity] GO:0006508 [proteolysis] Show all	344 aa 36.7 kDa	Yes	0
ADAMTS13-202 ENSP00000360984 ENST00000371916	E7EV88 [Direct mapping] A disintegrin and metalloproteinase with thrombospondin motifs 13 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004222 [metalloendopeptidase activity] GO:0005578 [proteinaceous extracellular matrix] GO:0006508 [proteolysis] GO:0008270 [zinc ion binding] Show all	444 aa 48.3 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.