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Cancer tissues showed weak to moderate nuclear membranous or nuclear staining. A few cases of melanoma and squamous cell carcinoma of skin showed strong positivity. Testicular and gastric cancers along with lymphoma were negative.
GENE INFORMATION
Gene name
GPSM1 (HGNC Symbol)
Synonyms
AGS3, DKFZP727I051
Description
G-protein signaling modulator 1 (HGNC Symbol)
Entrez gene summary
G-protein signaling modulators (GPSMs) play diverse functional roles through their interaction with G-protein subunits. This gene encodes a receptor-independent activator of G protein signaling, which is one of several factors that influence the basal activity of G-protein signaling systems. The protein contains seven tetratricopeptide repeats in its N-terminal half and four G-protein regulatory (GPR) motifs in its C-terminal half. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]