Expression of NLRP4 in cancer - Summary - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

NLRP4

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	NLRP4
Gene description	NLR family, pyrin domain containing 4
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	4
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enriched (testis cancer)
HPA (cell line):	Cell line enriched (Daudi)
HPA (normal tissue):	Tissue enhanced (testis, tonsil)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA042561
	SHOW MORE

PROGNOSTIC SUMMARY
Gene product is not prognostic.
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enriched (testis cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA042561

GENE INFORMATION
Gene name	NLRP4 (HGNC Symbol)
Synonyms	CLR19.5, CT58, FLJ32126, NALP4, PAN2, PYPAF4, RNH2
Description	NLR family, pyrin domain containing 4 (HGNC Symbol)
Entrez gene summary	NALPs are cytoplasmic proteins that form a subfamily within the larger CATERPILLER protein family. Most short NALPs, such as NALP4, have an N-terminal pyrin (MEFV; MIM 608107) domain (PYD), followed by a NACHT domain, a NACHT-associated domain (NAD), and a C-terminal leucine-rich repeat (LRR) region. The long NALP, NALP1 (MIM 606636), also has a C-terminal extension containing a function to find domain (FIIND) and a caspase recruitment domain (CARD). NALPs are implicated in the activation of proinflammatory caspases (e.g., CASP1; MIM 147678) via their involvement in multiprotein complexes called inflammasomes (Tschopp et al., 2003 [PubMed 12563287]).[supplied by OMIM, Mar 2008]
Chromosome	19
Cytoband	q13.43
Chromosome location (bp)	55836578 - 55881854
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000160505 (version 83.38)
Entrez gene	147945
UniProt	Q96MN2 (UniProt - Evidence at protein level)
neXtProt	NX_Q96MN2
Antibodypedia	NLRP4 antibodies

PROTEIN BROWSER

NLRP4-001	NLRP4-002	NLRP4-003	NLRP4-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
NLRP4-001 ENSP00000301295 ENST00000301295	Q96MN2 [Direct mapping] NACHT, LRR and PYD domains-containing protein 4 Show all	SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0005524 [ATP binding] GO:0005829 [cytosol] GO:0006954 [inflammatory response] GO:0032479 [regulation of type I interferon production] GO:0032481 [positive regulation of type I interferon production] GO:0045087 [innate immune response] GO:0070062 [extracellular exosome] Show all	994 aa 113.4 kDa	No	0
NLRP4-002 ENSP00000465463 ENST00000587891	Q96MN2 [Direct mapping] NACHT, LRR and PYD domains-containing protein 4 Show all	SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Phobius predicted secreted proteins Predicted intracellular proteins Show all	GO:0005524 [ATP binding] GO:0005829 [cytosol] GO:0006954 [inflammatory response] GO:0032479 [regulation of type I interferon production] GO:0032481 [positive regulation of type I interferon production] GO:0045087 [innate immune response] GO:0070062 [extracellular exosome] Show all	919 aa 104 kDa	No	0
NLRP4-003 ENSP00000468754 ENST00000589437	K7ESK5 [Direct mapping] NACHT, LRR and PYD domains-containing protein 4 Show all	Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Show all		504 aa 56.8 kDa	No	0
NLRP4-004 ENSP00000468496 ENST00000587464	K7ES09 [Direct mapping] NACHT, LRR and PYD domains-containing protein 4 Show all	Predicted intracellular proteins Show all		156 aa 18.9 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.