Tissue expression of NLRP4 - Summary - The Human Protein Atlas

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NLRP4

TISSUE

CELL

PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	NLRP4
Gene description	NLR family, pyrin domain containing 4
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enhanced (testis, tonsil)
GTEx:	Tissue enriched (testis)
FANTOM5:	Tissue enriched (tonsil)

Protein evidence

Evidence at protein level

Protein expression

Estimation of protein expression could not be performed. View primary data.

DATA RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA042561
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

N/A

Caudate

N/A

N/A

Cerebellum

N/A

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

N/A

Bronchus

N/A

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

N/A

Skin

N/A

Skin

N/A

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
RNA-based expert annotation could not be performed, due to inconclusive results. View immunohistochemistry primary data.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (testis, tonsil)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (testis)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (tonsil)

GENE INFORMATION
Gene name	NLRP4 (HGNC Symbol)
Synonyms	CLR19.5, CT58, FLJ32126, NALP4, PAN2, PYPAF4, RNH2
Description	NLR family, pyrin domain containing 4 (HGNC Symbol)
Entrez gene summary	NALPs are cytoplasmic proteins that form a subfamily within the larger CATERPILLER protein family. Most short NALPs, such as NALP4, have an N-terminal pyrin (MEFV; MIM 608107) domain (PYD), followed by a NACHT domain, a NACHT-associated domain (NAD), and a C-terminal leucine-rich repeat (LRR) region. The long NALP, NALP1 (MIM 606636), also has a C-terminal extension containing a function to find domain (FIIND) and a caspase recruitment domain (CARD). NALPs are implicated in the activation of proinflammatory caspases (e.g., CASP1; MIM 147678) via their involvement in multiprotein complexes called inflammasomes (Tschopp et al., 2003 [PubMed 12563287]).[supplied by OMIM, Mar 2008]
Chromosome	19
Cytoband	q13.43
Chromosome location (bp)	55836578 - 55881854
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000160505 (version 83.38)
Entrez gene	147945
UniProt	Q96MN2 (UniProt - Evidence at protein level)
neXtProt	NX_Q96MN2
Antibodypedia	NLRP4 antibodies

PROTEIN BROWSER

NLRP4-001	NLRP4-002	NLRP4-003	NLRP4-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
NLRP4-001 ENSP00000301295 ENST00000301295	Q96MN2 [Direct mapping] NACHT, LRR and PYD domains-containing protein 4 Show all	SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0005524 [ATP binding] GO:0005829 [cytosol] GO:0006954 [inflammatory response] GO:0032479 [regulation of type I interferon production] GO:0032481 [positive regulation of type I interferon production] GO:0045087 [innate immune response] GO:0070062 [extracellular exosome] Show all	994 aa 113.4 kDa	No	0
NLRP4-002 ENSP00000465463 ENST00000587891	Q96MN2 [Direct mapping] NACHT, LRR and PYD domains-containing protein 4 Show all	SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Phobius predicted secreted proteins Predicted intracellular proteins Show all	GO:0005524 [ATP binding] GO:0005829 [cytosol] GO:0006954 [inflammatory response] GO:0032479 [regulation of type I interferon production] GO:0032481 [positive regulation of type I interferon production] GO:0045087 [innate immune response] GO:0070062 [extracellular exosome] Show all	919 aa 104 kDa	No	0
NLRP4-003 ENSP00000468754 ENST00000589437	K7ESK5 [Direct mapping] NACHT, LRR and PYD domains-containing protein 4 Show all	Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Show all		504 aa 56.8 kDa	No	0
NLRP4-004 ENSP00000468496 ENST00000587464	K7ES09 [Direct mapping] NACHT, LRR and PYD domains-containing protein 4 Show all	Predicted intracellular proteins Show all		156 aa 18.9 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.