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DEDD2

GENERAL INFORMATION

Gene name

 DEDD2

Gene description

 Death effector domain containing 2

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Mixed
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Prognostic marker in urothelial cancer (favourable).
Urothelial cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 DEDD2 (HGNC Symbol)

Synonyms

 FLAME-3

Description

 Death effector domain containing 2 (HGNC Symbol)

Entrez gene summary

 This gene encodes a nuclear-localized protein containing a death effector domain (DED). The encoded protein may regulate the trafficking of caspases and other proteins into the nucleus during death receptor-induced apoptosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012]

Chromosome

 19

Cytoband

 q13.2

Chromosome location (bp)

 42198598 - 42220140

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000160570 (version 83.38)

Entrez gene

 162989

UniProt

 Q8WXF8 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8WXF8

Antibodypedia

 DEDD2 antibodies

PROTEIN BROWSER
DEDD2-001
DEDD2-003
DEDD2-010
DEDD2-011
DEDD2-013

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
DEDD2-001
ENSP00000470082
ENST00000595337
Q8WXF8 [Direct mapping]
DNA-binding death effector domain-containing protein 2
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Predicted intracellular proteins
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GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0006351 [transcription, DNA-templated]
GO:0006396 [RNA processing]
GO:0008625 [extrinsic apoptotic signaling pathway via death domain receptors]
GO:0016075 [rRNA catabolic process]
GO:0019725 [cellular homeostasis]
GO:0030159 [receptor signaling complex scaffold activity]
GO:0030262 [apoptotic nuclear changes]
GO:0035556 [intracellular signal transduction]
GO:0042981 [regulation of apoptotic process]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:2001238 [positive regulation of extrinsic apoptotic signaling pathway]
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 326 aa
36.2 kDa 		No 0
DEDD2-003
ENSP00000471512
ENST00000596251
Q8WXF8 [Direct mapping]
DNA-binding death effector domain-containing protein 2
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Predicted intracellular proteins
Show all
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0006351 [transcription, DNA-templated]
GO:0006396 [RNA processing]
GO:0008625 [extrinsic apoptotic signaling pathway via death domain receptors]
GO:0016075 [rRNA catabolic process]
GO:0019725 [cellular homeostasis]
GO:0030159 [receptor signaling complex scaffold activity]
GO:0030262 [apoptotic nuclear changes]
GO:0035556 [intracellular signal transduction]
GO:0042981 [regulation of apoptotic process]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:2001238 [positive regulation of extrinsic apoptotic signaling pathway]
Show all
 326 aa
36.2 kDa 		No 0
DEDD2-010
ENSP00000469233
ENST00000598727
M0QXK7 [Direct mapping]
DNA-binding death effector domain-containing protein 2
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Predicted intracellular proteins
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GO:0005515 [protein binding]
GO:0042981 [regulation of apoptotic process]
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 204 aa
22.6 kDa 		No 0
DEDD2-011
ENSP00000336972
ENST00000336034
Q8WXF8 [Direct mapping]
DNA-binding death effector domain-containing protein 2
Show all
Predicted intracellular proteins
Show all
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0006351 [transcription, DNA-templated]
GO:0006396 [RNA processing]
GO:0008625 [extrinsic apoptotic signaling pathway via death domain receptors]
GO:0016075 [rRNA catabolic process]
GO:0019725 [cellular homeostasis]
GO:0030159 [receptor signaling complex scaffold activity]
GO:0030262 [apoptotic nuclear changes]
GO:0035556 [intracellular signal transduction]
GO:0042981 [regulation of apoptotic process]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:2001238 [positive regulation of extrinsic apoptotic signaling pathway]
Show all
 321 aa
35.6 kDa 		No 0
DEDD2-013
ENSP00000469898
ENST00000598200
M0QYK9 [Direct mapping]
DNA-binding death effector domain-containing protein 2
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Predicted intracellular proteins
Show all
GO:0005515 [protein binding]
GO:0042981 [regulation of apoptotic process]
Show all
 118 aa
13.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.