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DEDD2

GENERAL INFORMATION

Gene name

 DEDD2

Gene description

 Death effector domain containing 2

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 5
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Mixed
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

DATA RELIABILITY

Reliability score

 Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
N/A
Hippocampus
N/A
N/A
Caudate
N/A
N/A
Cerebellum
N/A
N/A
Endocrine tissues
N/A
Bone marrow & immune system
N/A
Appendix
N/A
Tonsil
N/A
Spleen
N/A
Muscle tissues
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Oral mucosa
N/A
N/A
Esophagus
N/A
Stomach
N/A
Duodenum
N/A
Colon
N/A
Rectum
N/A
Kidney & urinary bladder
N/A
Kidney
N/A
Male tissues
N/A
Testis
N/A
Prostate
N/A
Female tissues
N/A
Breast
N/A
Vagina
N/A
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Soft tissue
N/A
N/A
Skin
N/A
Skin
N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 DEDD2 (HGNC Symbol)

Synonyms

 FLAME-3

Description

 Death effector domain containing 2 (HGNC Symbol)

Entrez gene summary

 This gene encodes a nuclear-localized protein containing a death effector domain (DED). The encoded protein may regulate the trafficking of caspases and other proteins into the nucleus during death receptor-induced apoptosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012]

Chromosome

 19

Cytoband

 q13.2

Chromosome location (bp)

 42198598 - 42220140

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000160570 (version 83.38)

Entrez gene

 162989

UniProt

 Q8WXF8 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8WXF8

Antibodypedia

 DEDD2 antibodies

PROTEIN BROWSER
DEDD2-001
DEDD2-003
DEDD2-010
DEDD2-011
DEDD2-013

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
DEDD2-001
ENSP00000470082
ENST00000595337
Q8WXF8 [Direct mapping]
DNA-binding death effector domain-containing protein 2
Show all
Predicted intracellular proteins
Show all
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0006351 [transcription, DNA-templated]
GO:0006396 [RNA processing]
GO:0008625 [extrinsic apoptotic signaling pathway via death domain receptors]
GO:0016075 [rRNA catabolic process]
GO:0019725 [cellular homeostasis]
GO:0030159 [receptor signaling complex scaffold activity]
GO:0030262 [apoptotic nuclear changes]
GO:0035556 [intracellular signal transduction]
GO:0042981 [regulation of apoptotic process]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:2001238 [positive regulation of extrinsic apoptotic signaling pathway]
Show all
 326 aa
36.2 kDa 		No 0
DEDD2-003
ENSP00000471512
ENST00000596251
Q8WXF8 [Direct mapping]
DNA-binding death effector domain-containing protein 2
Show all
Predicted intracellular proteins
Show all
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0006351 [transcription, DNA-templated]
GO:0006396 [RNA processing]
GO:0008625 [extrinsic apoptotic signaling pathway via death domain receptors]
GO:0016075 [rRNA catabolic process]
GO:0019725 [cellular homeostasis]
GO:0030159 [receptor signaling complex scaffold activity]
GO:0030262 [apoptotic nuclear changes]
GO:0035556 [intracellular signal transduction]
GO:0042981 [regulation of apoptotic process]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:2001238 [positive regulation of extrinsic apoptotic signaling pathway]
Show all
 326 aa
36.2 kDa 		No 0
DEDD2-010
ENSP00000469233
ENST00000598727
M0QXK7 [Direct mapping]
DNA-binding death effector domain-containing protein 2
Show all
Predicted intracellular proteins
Show all
GO:0005515 [protein binding]
GO:0042981 [regulation of apoptotic process]
Show all
 204 aa
22.6 kDa 		No 0
DEDD2-011
ENSP00000336972
ENST00000336034
Q8WXF8 [Direct mapping]
DNA-binding death effector domain-containing protein 2
Show all
Predicted intracellular proteins
Show all
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0006351 [transcription, DNA-templated]
GO:0006396 [RNA processing]
GO:0008625 [extrinsic apoptotic signaling pathway via death domain receptors]
GO:0016075 [rRNA catabolic process]
GO:0019725 [cellular homeostasis]
GO:0030159 [receptor signaling complex scaffold activity]
GO:0030262 [apoptotic nuclear changes]
GO:0035556 [intracellular signal transduction]
GO:0042981 [regulation of apoptotic process]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:2001238 [positive regulation of extrinsic apoptotic signaling pathway]
Show all
 321 aa
35.6 kDa 		No 0
DEDD2-013
ENSP00000469898
ENST00000598200
M0QYK9 [Direct mapping]
DNA-binding death effector domain-containing protein 2
Show all
Predicted intracellular proteins
Show all
GO:0005515 [protein binding]
GO:0042981 [regulation of apoptotic process]
Show all
 118 aa
13.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.