Cell atlas - NEK8 - The Human Protein Atlas

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NEK8

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION

GENE/PROTEIN

Dictionary

Human cell

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GENERAL INFORMATION
Gene name	NEK8
Gene description	NIMA-related kinase 8
Protein class	Disease related genes Enzymes Potential drug targets Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	4
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary
RNA cell category	Mixed
Protein evidence	Evidence at protein level
Main location	Not available

DATA RELIABILITY
Reliability score	Pending cell analysis.

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Mixed Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

GENE INFORMATION
Gene name	NEK8 (HGNC Symbol)
Synonyms	NPHP9
Description	NIMA-related kinase 8 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the serine/threionine protein kinase family related to NIMA (never in mitosis, gene A) of Aspergillus nidulans. The encoded protein may play a role in cell cycle progression from G2 to M phase. Mutations in the related mouse gene are associated with a disease phenotype that closely parallels the juvenile autosomal recessive form of polycystic kidney disease in humans. [provided by RefSeq, Jul 2008]
Chromosome	17
Cytoband	q11.2
Chromosome location (bp)	28725897 - 28743455
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000160602 (version 83.38)
Entrez gene	284086
UniProt	Q86SG6 (UniProt - Evidence at protein level)
neXtProt	NX_Q86SG6
Antibodypedia	NEK8 antibodies

PROTEIN BROWSER

NEK8-001	NEK8-003	NEK8-005	NEK8-008

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
NEK8-001 ENSP00000268766 ENST00000268766	Q86SG6 [Direct mapping] Serine/threonine-protein kinase Nek8 Show all	Enzymes ENZYME proteins Transferases Kinases NEK Ser/Thr protein kinases MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0005856 [cytoskeleton] GO:0005929 [cilium] GO:0006468 [protein phosphorylation] GO:0007017 [microtubule-based process] GO:0007368 [determination of left/right symmetry] GO:0007507 [heart development] GO:0009887 [organ morphogenesis] GO:0035330 [regulation of hippo signaling] GO:0046872 [metal ion binding] GO:0072372 [primary cilium] GO:0097543 [ciliary inversin compartment] GO:0097546 [ciliary base] Show all	692 aa 74.8 kDa	No	0
NEK8-003 ENSP00000467335 ENST00000579671	K7EPD3 [Direct mapping] Serine/threonine-protein kinase Nek8 Show all	MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Show all	GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] GO:0007017 [microtubule-based process] GO:0072372 [primary cilium] Show all	166 aa 19 kDa	No	0
NEK8-005 ENSP00000466896 ENST00000579060	K7END4 [Direct mapping] Serine/threonine-protein kinase Nek8 Show all	MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Show all	GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] GO:0007017 [microtubule-based process] GO:0072372 [primary cilium] Show all	167 aa 19.1 kDa	No	0
NEK8-008 ENSP00000466476 ENST00000592510	K7EMF0 [Direct mapping] Serine/threonine-protein kinase Nek8 Show all	Predicted intracellular proteins Show all	GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] GO:0007017 [microtubule-based process] GO:0072372 [primary cilium] Show all	261 aa 27.6 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.