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NEK8

GENERAL INFORMATION

Gene name

 NEK8

Gene description

 NIMA-related kinase 8

Protein class

 Disease related genes
Enzymes
Potential drug targets
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Mixed
GTEx:Mixed
FANTOM5:Mixed

Protein evidence

 Evidence at protein level

Protein expression

 Mainly cytoplasmic expression in most tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 2 antibodies.
HPA040661 , HPA040679
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed

GENE INFORMATION

Gene name

 NEK8 (HGNC Symbol)

Synonyms

 NPHP9

Description

 NIMA-related kinase 8 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the serine/threionine protein kinase family related to NIMA (never in mitosis, gene A) of Aspergillus nidulans. The encoded protein may play a role in cell cycle progression from G2 to M phase. Mutations in the related mouse gene are associated with a disease phenotype that closely parallels the juvenile autosomal recessive form of polycystic kidney disease in humans. [provided by RefSeq, Jul 2008]

Chromosome

 17

Cytoband

 q11.2

Chromosome location (bp)

 28725897 - 28743455

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000160602 (version 83.38)

Entrez gene

 284086

UniProt

 Q86SG6 (UniProt - Evidence at protein level)

neXtProt

 NX_Q86SG6

Antibodypedia

 NEK8 antibodies

PROTEIN BROWSER
NEK8-001
NEK8-003
NEK8-005
NEK8-008

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
NEK8-001
ENSP00000268766
ENST00000268766
Q86SG6 [Direct mapping]
Serine/threonine-protein kinase Nek8
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Enzymes
   ENZYME proteins
   Transferases
   Kinases
   NEK Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005856 [cytoskeleton]
GO:0005929 [cilium]
GO:0006468 [protein phosphorylation]
GO:0007017 [microtubule-based process]
GO:0007368 [determination of left/right symmetry]
GO:0007507 [heart development]
GO:0009887 [organ morphogenesis]
GO:0035330 [regulation of hippo signaling]
GO:0046872 [metal ion binding]
GO:0072372 [primary cilium]
GO:0097543 [ciliary inversin compartment]
GO:0097546 [ciliary base]
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 692 aa
74.8 kDa 		No 0
NEK8-003
ENSP00000467335
ENST00000579671
K7EPD3 [Direct mapping]
Serine/threonine-protein kinase Nek8
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   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Show all
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
GO:0007017 [microtubule-based process]
GO:0072372 [primary cilium]
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 166 aa
19 kDa 		No 0
NEK8-005
ENSP00000466896
ENST00000579060
K7END4 [Direct mapping]
Serine/threonine-protein kinase Nek8
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   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Show all
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
GO:0007017 [microtubule-based process]
GO:0072372 [primary cilium]
Show all
 167 aa
19.1 kDa 		No 0
NEK8-008
ENSP00000466476
ENST00000592510
K7EMF0 [Direct mapping]
Serine/threonine-protein kinase Nek8
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Predicted intracellular proteins
Show all
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
GO:0007017 [microtubule-based process]
GO:0072372 [primary cilium]
Show all
 261 aa
27.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.