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CXCR5

GENERAL INFORMATION

Gene name

 CXCR5

Gene description

 Chemokine (C-X-C motif) receptor 5

Protein class

 CD markers
G-protein coupled receptors
Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Not detected
HPA (cell line):Group enriched (Daudi, U-698)
HPA (normal tissue):Tissue enhanced (lymph node, spleen, tonsil)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in a subset of leukocytes.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA042432 , CAB026149
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Not detected

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Lymphoma

STAINING SUMMARY
HPA042432
CAB026149

GENE INFORMATION

Gene name

 CXCR5 (HGNC Symbol)

Synonyms

 BLR1, CD185, MDR15

Description

 Chemokine (C-X-C motif) receptor 5 (HGNC Symbol)

Entrez gene summary

 This gene encodes a multi-pass membrane protein that belongs to the CXC chemokine receptor family. It is expressed in mature B-cells and Burkitt's lymphoma. This cytokine receptor binds to B-lymphocyte chemoattractant (BLC), and is involved in B-cell migration into B-cell follicles of spleen and Peyer patches. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]

Chromosome

 11

Cytoband

 q23.3

Chromosome location (bp)

 118883766 - 118897799

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000160683 (version 83.38)

Entrez gene

 643

UniProt

 P32302 (UniProt - Evidence at protein level)

neXtProt

 NX_P32302

Antibodypedia

 CXCR5 antibodies

PROTEIN BROWSER
CXCR5-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CXCR5-001
ENSP00000292174
ENST00000292174
P32302 [Direct mapping]
C-X-C chemokine receptor type 5
A0N0R2 [Target identity:100%; Query identity:100%]
Burkitt lymphoma receptor 1, GTP binding protein (Chemokine (C-X-C motif) receptor 5); Burkitt lymphoma receptor 1, GTP binding protein (Chemokine (C-X-C motif) receptor 5), isoform CRA_a; C-x-c chemokine receptor type 5
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CD markers
G-protein coupled receptors
   GPCRs excl olfactory receptors
   Chemokines and chemotactic factors receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
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GO:0004930 [G-protein coupled receptor activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006928 [movement of cell or subcellular component]
GO:0006935 [chemotaxis]
GO:0006955 [immune response]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0009897 [external side of plasma membrane]
GO:0016021 [integral component of membrane]
GO:0016494 [C-X-C chemokine receptor activity]
GO:0032467 [positive regulation of cytokinesis]
GO:0042113 [B cell activation]
GO:0048535 [lymph node development]
GO:0070098 [chemokine-mediated signaling pathway]
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 372 aa
42 kDa 		No 7

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.