Cell atlas - NLRX1 - The Human Protein Atlas

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NLRX1

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TISSUE

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CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cell Junctions
	Mitochondria
	Plasma membrane

Human cell
	Mitochondria
	Plasma Membrane

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GENERAL INFORMATION
Gene name	NLRX1
Gene description	NLR family member X1
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	8
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the mitochondria. In addition localized to the plasma membrane & cell junctions.
RNA cell category	Mixed
Protein evidence	Evidence at protein level
Main location	Localized to the Mitochondria (supported)
Additional location	In addition localized to the Plasma membrane (approved), Cell Junctions (approved)

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA061516
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Mixed Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the mitochondria. In addition localized to the plasma membrane & cell junctions.

Main location

Mitochondria (supported)

Additional location

Plasma membrane (approved), Cell Junctions (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA061516	A549	Plasma membrane
	HPA061516	A549	Mitochondria
	HPA061516	MCF7	Cell Junctions
	HPA061516	MCF7	Mitochondria
	HPA061516	U-2 OS	Mitochondria

GENE INFORMATION
Gene name	NLRX1 (HGNC Symbol)
Synonyms	CLR11.3, NOD9
Description	NLR family member X1 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a member of the NLR family and localizes to the outer mitochondrial membrane. The encoded protein is a regulator of mitochondrial antivirus responses. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Aug 2013]
Chromosome	11
Cytoband	q23.3
Chromosome location (bp)	119166568 - 119184016
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000160703 (version 83.38)
Entrez gene	79671
UniProt	Q86UT6 (UniProt - Evidence at protein level)
neXtProt	NX_Q86UT6
Antibodypedia	NLRX1 antibodies

PROTEIN BROWSER

NLRX1-001	NLRX1-003	NLRX1-004	NLRX1-005	NLRX1-006	NLRX1-008	NLRX1-009	NLRX1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
NLRX1-001 ENSP00000292199 ENST00000292199	Q86UT6 [Direct mapping] NLR family member X1 Show all	SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005741 [mitochondrial outer membrane] GO:0016032 [viral process] GO:0032480 [negative regulation of type I interferon production] GO:0045087 [innate immune response] Show all	975 aa 107.6 kDa	No	0
NLRX1-003 ENSP00000386851 ENST00000409991	Q86UT6 [Direct mapping] NLR family member X1 Show all	SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005741 [mitochondrial outer membrane] GO:0016032 [viral process] GO:0032480 [negative regulation of type I interferon production] GO:0045087 [innate immune response] Show all	975 aa 107.6 kDa	No	0
NLRX1-004 ENSP00000387334 ENST00000409109	Q86UT6 [Direct mapping] NLR family member X1 Show all	SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005739 [mitochondrion] GO:0005741 [mitochondrial outer membrane] GO:0016032 [viral process] GO:0032480 [negative regulation of type I interferon production] GO:0032688 [negative regulation of interferon-beta production] GO:0032715 [negative regulation of interleukin-6 production] GO:0039536 [negative regulation of RIG-I signaling pathway] GO:0043124 [negative regulation of I-kappaB kinase/NF-kappaB signaling] GO:0045087 [innate immune response] GO:0045824 [negative regulation of innate immune response] GO:0050728 [negative regulation of inflammatory response] Show all	975 aa 107.6 kDa	No	0
NLRX1-005 ENSP00000433442 ENST00000525863	Q86UT6 [Direct mapping] NLR family member X1 Show all	SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005741 [mitochondrial outer membrane] GO:0016032 [viral process] GO:0032480 [negative regulation of type I interferon production] GO:0045087 [innate immune response] Show all	921 aa 101.9 kDa	No	0
NLRX1-006 ENSP00000400268 ENST00000454811	C9J0R6 [Direct mapping] NLR family member X1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		151 aa 17.3 kDa	No	0
NLRX1-008 ENSP00000402801 ENST00000449394	C9JQE9 [Direct mapping] NLR family member X1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		137 aa 15.8 kDa	No	0
NLRX1-009 ENSP00000402381 ENST00000422249	C9JLK8 [Direct mapping] NLR family member X1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		127 aa 14.7 kDa	No	0
NLRX1-201 ENSP00000386858 ENST00000409265	Q86UT6 [Direct mapping] NLR family member X1 Show all	SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005741 [mitochondrial outer membrane] GO:0016032 [viral process] GO:0032480 [negative regulation of type I interferon production] GO:0045087 [innate immune response] Show all	975 aa 107.6 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.