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NLRX1

GENERAL INFORMATION

Gene name

 NLRX1

Gene description

 NLR family member X1

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 8
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Mixed
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General cytoplasmic expression with a mitochondrial pattern.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
HPA061516
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable) and endometrial cancer (favourable).
Renal cancer p<0.001
Endometrial cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA061516

GENE INFORMATION

Gene name

 NLRX1 (HGNC Symbol)

Synonyms

 CLR11.3, NOD9

Description

 NLR family member X1 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a member of the NLR family and localizes to the outer mitochondrial membrane. The encoded protein is a regulator of mitochondrial antivirus responses. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Aug 2013]

Chromosome

 11

Cytoband

 q23.3

Chromosome location (bp)

 119166568 - 119184016

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000160703 (version 83.38)

Entrez gene

 79671

UniProt

 Q86UT6 (UniProt - Evidence at protein level)

neXtProt

 NX_Q86UT6

Antibodypedia

 NLRX1 antibodies

PROTEIN BROWSER
NLRX1-001
NLRX1-003
NLRX1-004
NLRX1-005
NLRX1-006
NLRX1-008
NLRX1-009
NLRX1-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
NLRX1-001
ENSP00000292199
ENST00000292199
Q86UT6 [Direct mapping]
NLR family member X1
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   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005741 [mitochondrial outer membrane]
GO:0016032 [viral process]
GO:0032480 [negative regulation of type I interferon production]
GO:0045087 [innate immune response]
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 975 aa
107.6 kDa 		No 0
NLRX1-003
ENSP00000386851
ENST00000409991
Q86UT6 [Direct mapping]
NLR family member X1
Show all
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005741 [mitochondrial outer membrane]
GO:0016032 [viral process]
GO:0032480 [negative regulation of type I interferon production]
GO:0045087 [innate immune response]
Show all
 975 aa
107.6 kDa 		No 0
NLRX1-004
ENSP00000387334
ENST00000409109
Q86UT6 [Direct mapping]
NLR family member X1
Show all
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005739 [mitochondrion]
GO:0005741 [mitochondrial outer membrane]
GO:0016032 [viral process]
GO:0032480 [negative regulation of type I interferon production]
GO:0032688 [negative regulation of interferon-beta production]
GO:0032715 [negative regulation of interleukin-6 production]
GO:0039536 [negative regulation of RIG-I signaling pathway]
GO:0043124 [negative regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0045087 [innate immune response]
GO:0045824 [negative regulation of innate immune response]
GO:0050728 [negative regulation of inflammatory response]
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 975 aa
107.6 kDa 		No 0
NLRX1-005
ENSP00000433442
ENST00000525863
Q86UT6 [Direct mapping]
NLR family member X1
Show all
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005741 [mitochondrial outer membrane]
GO:0016032 [viral process]
GO:0032480 [negative regulation of type I interferon production]
GO:0045087 [innate immune response]
Show all
 921 aa
101.9 kDa 		No 0
NLRX1-006
ENSP00000400268
ENST00000454811
C9J0R6 [Direct mapping]
NLR family member X1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 151 aa
17.3 kDa 		No 0
NLRX1-008
ENSP00000402801
ENST00000449394
C9JQE9 [Direct mapping]
NLR family member X1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 137 aa
15.8 kDa 		No 0
NLRX1-009
ENSP00000402381
ENST00000422249
C9JLK8 [Direct mapping]
NLR family member X1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 127 aa
14.7 kDa 		No 0
NLRX1-201
ENSP00000386858
ENST00000409265
Q86UT6 [Direct mapping]
NLR family member X1
Show all
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005741 [mitochondrial outer membrane]
GO:0016032 [viral process]
GO:0032480 [negative regulation of type I interferon production]
GO:0045087 [innate immune response]
Show all
 975 aa
107.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.