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RUSC1

GENERAL INFORMATION

Gene name

 RUSC1

Gene description

 RUN and SH3 domain containing 1

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 11
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Granular cytoplasmic expression in most tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 3 antibodies.
HPA028510 , HPA029922 , HPA029923
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Cerebellum

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 RUSC1 (HGNC Symbol)

Synonyms

 NESCA

Description

 RUN and SH3 domain containing 1 (HGNC Symbol)

Entrez gene summary

Chromosome

 1

Cytoband

 q22

Chromosome location (bp)

 155320896 - 155331114

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000160753 (version 83.38)

Entrez gene

 23623

UniProt

 Q9BVN2 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9BVN2

Antibodypedia

 RUSC1 antibodies

PROTEIN BROWSER
«
RUSC1-001
RUSC1-002
RUSC1-003
RUSC1-004
RUSC1-005
RUSC1-007
RUSC1-008
RUSC1-011
RUSC1-012
RUSC1-014
RUSC1-017
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
RUSC1-001
ENSP00000357336
ENST00000368352
Q9BVN2 [Direct mapping]
RUN and SH3 domain-containing protein 1
Show all
   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000209 [protein polyubiquitination]
GO:0003779 [actin binding]
GO:0005070 [SH3/SH2 adaptor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005769 [early endosome]
GO:0005794 [Golgi apparatus]
GO:0005874 [microtubule]
GO:0009967 [positive regulation of signal transduction]
GO:0014069 [postsynaptic density]
GO:0015630 [microtubule cytoskeleton]
GO:0016023 [cytoplasmic membrane-bounded vesicle]
GO:0030054 [cell junction]
GO:0031410 [cytoplasmic vesicle]
GO:0045211 [postsynaptic membrane]
Show all
 902 aa
96.4 kDa 		No 0
RUSC1-002
ENSP00000357338
ENST00000368354
Q9BVN2 [Direct mapping]
RUN and SH3 domain-containing protein 1
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000209 [protein polyubiquitination]
GO:0003779 [actin binding]
GO:0005070 [SH3/SH2 adaptor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005769 [early endosome]
GO:0005794 [Golgi apparatus]
GO:0005874 [microtubule]
GO:0009967 [positive regulation of signal transduction]
GO:0014069 [postsynaptic density]
GO:0015630 [microtubule cytoskeleton]
GO:0016023 [cytoplasmic membrane-bounded vesicle]
GO:0030054 [cell junction]
GO:0031410 [cytoplasmic vesicle]
GO:0045211 [postsynaptic membrane]
Show all
 796 aa
85.2 kDa 		No 0
RUSC1-003
ENSP00000357331
ENST00000368347
Q9BVN2 [Direct mapping]
RUN and SH3 domain-containing protein 1
Show all
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000209 [protein polyubiquitination]
GO:0003779 [actin binding]
GO:0005070 [SH3/SH2 adaptor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005769 [early endosome]
GO:0005794 [Golgi apparatus]
GO:0005874 [microtubule]
GO:0009967 [positive regulation of signal transduction]
GO:0014069 [postsynaptic density]
GO:0015630 [microtubule cytoskeleton]
GO:0016023 [cytoplasmic membrane-bounded vesicle]
GO:0030054 [cell junction]
GO:0031410 [cytoplasmic vesicle]
GO:0045211 [postsynaptic membrane]
Show all
 492 aa
52.8 kDa 		No 0
RUSC1-004
ENSP00000357333
ENST00000368349
Q9BVN2 [Direct mapping]
RUN and SH3 domain-containing protein 1
Show all
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000209 [protein polyubiquitination]
GO:0003779 [actin binding]
GO:0005070 [SH3/SH2 adaptor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005769 [early endosome]
GO:0005794 [Golgi apparatus]
GO:0005874 [microtubule]
GO:0009967 [positive regulation of signal transduction]
GO:0014069 [postsynaptic density]
GO:0015630 [microtubule cytoskeleton]
GO:0016023 [cytoplasmic membrane-bounded vesicle]
GO:0030054 [cell junction]
GO:0031410 [cytoplasmic vesicle]
GO:0045211 [postsynaptic membrane]
Show all
 433 aa
46.6 kDa 		No 0
RUSC1-005
ENSP00000292254
ENST00000292254
Q9BVN2 [Direct mapping]
RUN and SH3 domain-containing protein 1
Show all
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000209 [protein polyubiquitination]
GO:0003779 [actin binding]
GO:0005070 [SH3/SH2 adaptor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005769 [early endosome]
GO:0005794 [Golgi apparatus]
GO:0005874 [microtubule]
GO:0009967 [positive regulation of signal transduction]
GO:0014069 [postsynaptic density]
GO:0015630 [microtubule cytoskeleton]
GO:0016023 [cytoplasmic membrane-bounded vesicle]
GO:0030054 [cell junction]
GO:0031410 [cytoplasmic vesicle]
GO:0045211 [postsynaptic membrane]
Show all
 433 aa
46.6 kDa 		No 0
RUSC1-007
ENSP00000484026
ENST00000490373
Q68CX2 [Direct mapping]
Putative uncharacterized protein DKFZp761A1822; RUN and SH3 domain-containing protein 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
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 211 aa
22.8 kDa 		No 0
RUSC1-008
ENSP00000482409
ENST00000471876
A0A087WZ68 [Direct mapping]
RUN and SH3 domain containing 1, isoform CRA_b; RUN and SH3 domain-containing protein 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
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 127 aa
13.8 kDa 		No 0
RUSC1-011
ENSP00000479858
ENST00000497930
A0A087WW20 [Direct mapping]
RUN and SH3 domain-containing protein 1
Show all
   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 301 aa
32.3 kDa 		No 0
RUSC1-012
ENSP00000479495
ENST00000489860
A0A087WVK5 [Direct mapping]
RUN and SH3 domain-containing protein 1
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   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 265 aa
28.5 kDa 		No 0
RUSC1-014
ENSP00000480831
ENST00000479924
A0A087WX95 [Direct mapping]
RUN and SH3 domain-containing protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 271 aa
29.1 kDa 		No 0
RUSC1-017
ENSP00000481669
ENST00000485924
A0A087WYB2 [Direct mapping]
RUN and SH3 domain-containing protein 1
Show all
   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 225 aa
24 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.