Expression of FAM189B in cancer - Summary - The Human Protein Atlas

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FAM189B

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	FAM189B
Gene description	Family with sequence similarity 189, member B
Protein class	Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA006659
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable), endometrial cancer (unfavourable), liver cancer (unfavourable) and cervical cancer (unfavourable).
Renal cancer p<0.001 Endometrial cancer p<0.001 Liver cancer p<0.001 Cervical cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA006659

GENE INFORMATION
Gene name	FAM189B (HGNC Symbol)
Synonyms	C1orf2, cote1
Description	Family with sequence similarity 189, member B (HGNC Symbol)
Entrez gene summary	This gene is located near the gene for the lysosomal enzyme glucosylceramidase; a deficiency in this enzyme is associated with Gaucher disease. The encoded protein has been identified as a potential binding partner of a WW domain-containing protein which is involved in apoptosis and tumor suppression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2010]
Chromosome	1
Cytoband	q22
Chromosome location (bp)	155247205 - 155255483
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000160767 (version 83.38)
Entrez gene	10712
UniProt	P81408 (UniProt - Evidence at protein level)
neXtProt	NX_P81408
Antibodypedia	FAM189B antibodies

PROTEIN BROWSER

FAM189B-001	FAM189B-002	FAM189B-004	FAM189B-008	FAM189B-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
FAM189B-001 ENSP00000354958 ENST00000361361	P81408 [Direct mapping] Protein FAM189B Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Show all	GO:0005515 [protein binding] GO:0008150 [biological_process] GO:0016021 [integral component of membrane] GO:0050699 [WW domain binding] Show all	668 aa 71.4 kDa	No	4
FAM189B-002 ENSP00000307128 ENST00000350210	P81408 [Direct mapping] Protein FAM189B Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Show all	GO:0005515 [protein binding] GO:0008150 [biological_process] GO:0016021 [integral component of membrane] GO:0050699 [WW domain binding] Show all	572 aa 61.1 kDa	No	2
FAM189B-004 ENSP00000357352 ENST00000368368	P81408 [Direct mapping] Protein FAM189B Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Show all	GO:0005515 [protein binding] GO:0008150 [biological_process] GO:0016021 [integral component of membrane] GO:0050699 [WW domain binding] Show all	650 aa 69.4 kDa	No	3
FAM189B-008 ENSP00000427011 ENST00000491082	D6RD59 [Direct mapping] Protein FAM189B Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Show all	GO:0016021 [integral component of membrane] Show all	325 aa 34.9 kDa	No	2
FAM189B-201 ENSP00000479323 ENST00000621094	Q96H71 [Direct mapping] C1orf2 protein; Protein FAM189B Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Show all	GO:0005515 [protein binding] GO:0016021 [integral component of membrane] Show all	242 aa 26.1 kDa	No	2

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.