Cell atlas - CYP3A7 - The Human Protein Atlas

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CYP3A7

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol

Human cell
	Cytosol

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GENERAL INFORMATION
Gene name	CYP3A7
Gene description	Cytochrome P450, family 3, subfamily A, polypeptide 7
Protein class	Enzymes Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the cytosol. Caution: Based on antibodies targeting proteins from multiple genes.
RNA cell category	Cell line enhanced (Hep G2, BJ hTERT+)
Protein evidence	Evidence at protein level
Main location	Localized to the Cytosol (uncertain)

DATA RELIABILITY
Reliability score	Uncertain based on 1 antibody. HPA072245
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (Hep G2, BJ hTERT+) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the cytosol. Caution: Based on antibodies targeting proteins from multiple genes.

Main location

Cytosol (uncertain)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA072245	Hep G2	Cytosol
	HPA072245	U-2 OS	Cytosol

GENE INFORMATION
Gene name	CYP3A7 (HGNC Symbol)
Synonyms	CP37, P450-HFLA
Description	Cytochrome P450, family 3, subfamily A, polypeptide 7 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the cytochrome P450 superfamily of enzymes, which participate in drug metabolism and the synthesis of cholesterol, steroids and other lipids. This enzyme hydroxylates testosterone and dehydroepiandrosterone 3-sulphate, which is involved in the formation of estriol during pregnancy. This gene is part of a cluster of related genes on chromosome 7q21.1. Naturally-occurring readthrough transcription occurs between this gene and the downstream CYP3A51P pseudogene and is represented by GeneID:100861540. [provided by RefSeq, Jan 2015]
Chromosome	7
Cytoband	q22.1
Chromosome location (bp)	99705037 - 99735196
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000160870 (version 83.38)
Entrez gene	1551
UniProt	P24462 (UniProt - Evidence at protein level)
neXtProt	NX_P24462
Antibodypedia	CYP3A7 antibodies

PROTEIN BROWSER

CYP3A7-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CYP3A7-001 ENSP00000337450 ENST00000336374	P24462 [Direct mapping] Cytochrome P450 3A7 Show all	Enzymes ENZYME proteins Oxidoreductases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004497 [monooxygenase activity] GO:0005506 [iron ion binding] GO:0005789 [endoplasmic reticulum membrane] GO:0006805 [xenobiotic metabolic process] GO:0016705 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen] GO:0019825 [oxygen binding] GO:0020037 [heme binding] GO:0044281 [small molecule metabolic process] GO:0055114 [oxidation-reduction process] GO:0070330 [aromatase activity] Show all	503 aa 57.5 kDa	No	1

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.