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CYP3A7

GENERAL INFORMATION

Gene name

 CYP3A7

Gene description

 Cytochrome P450, family 3, subfamily A, polypeptide 7

Protein class

 Enzymes
Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enriched (liver cancer)
HPA (cell line):Cell line enhanced (BJ hTERT+, Hep G2)
HPA (normal tissue):Tissue enriched (liver)

Protein evidence

 Evidence at protein level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enriched (liver cancer)

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 CYP3A7 (HGNC Symbol)

Synonyms

 CP37, P450-HFLA

Description

 Cytochrome P450, family 3, subfamily A, polypeptide 7 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the cytochrome P450 superfamily of enzymes, which participate in drug metabolism and the synthesis of cholesterol, steroids and other lipids. This enzyme hydroxylates testosterone and dehydroepiandrosterone 3-sulphate, which is involved in the formation of estriol during pregnancy. This gene is part of a cluster of related genes on chromosome 7q21.1. Naturally-occurring readthrough transcription occurs between this gene and the downstream CYP3A51P pseudogene and is represented by GeneID:100861540. [provided by RefSeq, Jan 2015]

Chromosome

 7

Cytoband

 q22.1

Chromosome location (bp)

 99705037 - 99735196

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000160870 (version 83.38)

Entrez gene

 1551

UniProt

 P24462 (UniProt - Evidence at protein level)

neXtProt

 NX_P24462

Antibodypedia

 CYP3A7 antibodies

PROTEIN BROWSER
CYP3A7-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CYP3A7-001
ENSP00000337450
ENST00000336374
P24462 [Direct mapping]
Cytochrome P450 3A7
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Enzymes
   ENZYME proteins
   Oxidoreductases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
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GO:0004497 [monooxygenase activity]
GO:0005506 [iron ion binding]
GO:0005789 [endoplasmic reticulum membrane]
GO:0006805 [xenobiotic metabolic process]
GO:0016705 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen]
GO:0019825 [oxygen binding]
GO:0020037 [heme binding]
GO:0044281 [small molecule metabolic process]
GO:0055114 [oxidation-reduction process]
GO:0070330 [aromatase activity]
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 503 aa
57.5 kDa 		No 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.