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LRWD1

GENERAL INFORMATION

Gene name

 LRWD1

Gene description

 Leucine-rich repeats and WD repeat domain containing 1

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Tissue enriched (testis)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Nuclear expression in testis.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Presumed off target binding observed and disregarded.

Reliability score

 Supported based on 1 antibody.
HPA021320
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PROGNOSTIC SUMMARY
Prognostic marker in pancreatic cancer (favourable) and renal cancer (unfavourable).
Pancreatic cancer p<0.001
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA021320

GENE INFORMATION

Gene name

 LRWD1 (HGNC Symbol)

Synonyms

 CENP-33, DKFZp434K1815, ORCA

Description

 Leucine-rich repeats and WD repeat domain containing 1 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene interacts with components of the origin recognition complex (ORC) and regulates the formation of the prereplicative complex. The encoded protein stabilizes the ORC and therefore aids in DNA replication. This protein is required for the G1/S phase transition of the cell cycle. In addition, the encoded protein binds to trimethylated histone H3 in heterochromatin and recruits the ORC and lysine methyltransferases, which help maintain the repressive heterochromatic state. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015]

Chromosome

 7

Cytoband

 q22.1

Chromosome location (bp)

 102464929 - 102473168

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000161036 (version 83.38)

Entrez gene

 222229

UniProt

 Q9UFC0 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9UFC0

Antibodypedia

 LRWD1 antibodies

PROTEIN BROWSER
LRWD1-001
LRWD1-004
LRWD1-009
LRWD1-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
LRWD1-001
ENSP00000292616
ENST00000292616
Q9UFC0 [Direct mapping]
Leucine-rich repeat and WD repeat-containing protein 1
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   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0003682 [chromatin binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005664 [nuclear origin of replication recognition complex]
GO:0005721 [pericentric heterochromatin]
GO:0005737 [cytoplasm]
GO:0005815 [microtubule organizing center]
GO:0006270 [DNA replication initiation]
GO:0006325 [chromatin organization]
GO:0008327 [methyl-CpG binding]
GO:0016568 [chromatin modification]
GO:0031933 [telomeric heterochromatin]
GO:0035064 [methylated histone binding]
GO:0071169 [establishment of protein localization to chromatin]
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 647 aa
70.9 kDa 		No 0
LRWD1-004
ENSP00000420650
ENST00000463739
F8WDB4 [Direct mapping]
Leucine-rich repeat and WD repeat-containing protein 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 154 aa
16.7 kDa 		No 0
LRWD1-009
ENSP00000420373
ENST00000468175
H7C5N7 [Direct mapping]
Leucine-rich repeat and WD repeat-containing protein 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
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 242 aa
26.3 kDa 		No 0
LRWD1-201
ENSP00000487494
ENST00000626402
F8WBP5 [Direct mapping]
Leucine-rich repeat and WD repeat-containing protein 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 45 aa
4.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.