Cell atlas - BDH1 - The Human Protein Atlas

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BDH1

TISSUE

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CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Mitochondria

Human cell
	Mitochondria

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GENERAL INFORMATION
Gene name	BDH1
Gene description	3-hydroxybutyrate dehydrogenase, type 1
Protein class	Candidate cardiovascular disease genes Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	10
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the mitochondria.
RNA cell category	Cell line enhanced (U-937)
Protein evidence	Evidence at protein level
Main location	Localized to the Mitochondria (validated)

DATA RELIABILITY
Reliability score	Validated based on 2 antibodies. HPA030947 , HPA058709
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (U-937) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the mitochondria.

Main location

Mitochondria (validated)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA030947	A-431	Nucleoplasm
	HPA030947	A-431	Mitochondria
	HPA030947	U-2 OS	Nucleoplasm
	HPA030947	U-2 OS	Mitochondria
	HPA030947	U-251 MG	Nucleoplasm
	HPA030947	U-251 MG	Mitochondria
	HPA058709	MCF7	Mitochondria
	HPA058709	U-2 OS	No staining

GENE INFORMATION
Gene name	BDH1 (HGNC Symbol)
Synonyms	BDH, SDR9C1
Description	3-hydroxybutyrate dehydrogenase, type 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the short-chain dehydrogenase/reductase gene family. The encoded protein forms a homotetrameric lipid-requiring enzyme of the mitochondrial membrane and has a specific requirement for phosphatidylcholine for optimal enzymatic activity. The encoded protein catalyzes the interconversion of acetoacetate and (R)-3-hydroxybutyrate, the two major ketone bodies produced during fatty acid catabolism. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008]
Chromosome	3
Cytoband	q29
Chromosome location (bp)	197509783 - 197573323
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000161267 (version 83.38)
Entrez gene	622
UniProt	Q02338 (UniProt - Evidence at protein level)
neXtProt	NX_Q02338
Antibodypedia	BDH1 antibodies

PROTEIN BROWSER

BDH1-001	BDH1-002	BDH1-006	BDH1-008	BDH1-009	BDH1-011	BDH1-015	BDH1-016	BDH1-201	BDH1-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
BDH1-001 ENSP00000376183 ENST00000392378	Q02338 [Direct mapping] D-beta-hydroxybutyrate dehydrogenase, mitochondrial Show all	Enzymes ENZYME proteins Oxidoreductases MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Candidate cardiovascular disease genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003858 [3-hydroxybutyrate dehydrogenase activity] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005759 [mitochondrial matrix] GO:0008152 [metabolic process] GO:0016491 [oxidoreductase activity] GO:0044255 [cellular lipid metabolic process] GO:0044281 [small molecule metabolic process] GO:0046950 [cellular ketone body metabolic process] GO:0046951 [ketone body biosynthetic process] GO:0046952 [ketone body catabolic process] GO:0055114 [oxidation-reduction process] Show all	343 aa 38.2 kDa	No	0
BDH1-002 ENSP00000411014 ENST00000441275	E9PCG9 [Direct mapping] D-beta-hydroxybutyrate dehydrogenase, mitochondrial Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005654 [nucleoplasm] GO:0005739 [mitochondrion] GO:0008152 [metabolic process] GO:0016491 [oxidoreductase activity] GO:0055114 [oxidation-reduction process] Show all	256 aa 29 kDa	No	0
BDH1-006 ENSP00000409849 ENST00000432819	C9JQ90 [Direct mapping] D-beta-hydroxybutyrate dehydrogenase, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0008152 [metabolic process] GO:0016491 [oxidoreductase activity] GO:0055114 [oxidation-reduction process] Show all	186 aa 20.3 kDa	No	0
BDH1-008 ENSP00000387648 ENST00000446746	C9K0G7 [Direct mapping] D-beta-hydroxybutyrate dehydrogenase, mitochondrial Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008152 [metabolic process] GO:0016491 [oxidoreductase activity] GO:0055114 [oxidation-reduction process] Show all	166 aa 18.4 kDa	No	0
BDH1-009 ENSP00000405462 ENST00000445160	C9JB83 [Direct mapping] D-beta-hydroxybutyrate dehydrogenase, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		50 aa 5.4 kDa	No	0
BDH1-011 ENSP00000408685 ENST00000434143	C9JM78 [Direct mapping] D-beta-hydroxybutyrate dehydrogenase, mitochondrial Show all	SPOCTOPUS predicted membrane proteins Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0008152 [metabolic process] GO:0016491 [oxidoreductase activity] GO:0055114 [oxidation-reduction process] Show all	169 aa 18.4 kDa	No	0
BDH1-015 ENSP00000408016 ENST00000455876	H7C2W1 [Direct mapping] D-beta-hydroxybutyrate dehydrogenase, mitochondrial Show all	SCAMPI predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008152 [metabolic process] GO:0016491 [oxidoreductase activity] GO:0055114 [oxidation-reduction process] Show all	129 aa 14.5 kDa	No	0
BDH1-016 ENSP00000396149 ENST00000431056	C9JEB9 [Direct mapping] D-beta-hydroxybutyrate dehydrogenase, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		89 aa 9.4 kDa	No	0
BDH1-201 ENSP00000350914 ENST00000358186	Q02338 [Direct mapping] D-beta-hydroxybutyrate dehydrogenase, mitochondrial Show all	Enzymes ENZYME proteins Oxidoreductases MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Candidate cardiovascular disease genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003858 [3-hydroxybutyrate dehydrogenase activity] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005759 [mitochondrial matrix] GO:0008152 [metabolic process] GO:0016491 [oxidoreductase activity] GO:0044255 [cellular lipid metabolic process] GO:0044281 [small molecule metabolic process] GO:0046950 [cellular ketone body metabolic process] GO:0046951 [ketone body biosynthetic process] GO:0046952 [ketone body catabolic process] GO:0055114 [oxidation-reduction process] Show all	343 aa 38.2 kDa	No	0
BDH1-202 ENSP00000376184 ENST00000392379	Q02338 [Direct mapping] D-beta-hydroxybutyrate dehydrogenase, mitochondrial Show all	Enzymes ENZYME proteins Oxidoreductases MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Candidate cardiovascular disease genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001889 [liver development] GO:0003858 [3-hydroxybutyrate dehydrogenase activity] GO:0005543 [phospholipid binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005743 [mitochondrial inner membrane] GO:0005759 [mitochondrial matrix] GO:0007420 [brain development] GO:0007584 [response to nutrient] GO:0008152 [metabolic process] GO:0009636 [response to toxic substance] GO:0009725 [response to hormone] GO:0016491 [oxidoreductase activity] GO:0032355 [response to estradiol] GO:0032868 [response to insulin] GO:0042493 [response to drug] GO:0042594 [response to starvation] GO:0044255 [cellular lipid metabolic process] GO:0044281 [small molecule metabolic process] GO:0045471 [response to ethanol] GO:0046686 [response to cadmium ion] GO:0046950 [cellular ketone body metabolic process] GO:0046951 [ketone body biosynthetic process] GO:0046952 [ketone body catabolic process] GO:0051412 [response to corticosterone] GO:0055114 [oxidation-reduction process] GO:0060416 [response to growth hormone] GO:0060612 [adipose tissue development] Show all	343 aa 38.2 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.