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Moderate to strong granular cytoplasmic positivity was observed in most malignancies. Malignant gliomas and skin cancer as well as several lung and renal cancers were negative or weakly stained.
GENE INFORMATION
Gene name
BDH1 (HGNC Symbol)
Synonyms
BDH, SDR9C1
Description
3-hydroxybutyrate dehydrogenase, type 1 (HGNC Symbol)
Entrez gene summary
This gene encodes a member of the short-chain dehydrogenase/reductase gene family. The encoded protein forms a homotetrameric lipid-requiring enzyme of the mitochondrial membrane and has a specific requirement for phosphatidylcholine for optimal enzymatic activity. The encoded protein catalyzes the interconversion of acetoacetate and (R)-3-hydroxybutyrate, the two major ketone bodies produced during fatty acid catabolism. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008]