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AQP5

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GENERAL INFORMATION

Gene name

 AQP5

Gene description

 Aquaporin 5

Protein class

 Disease related genes
Potential drug targets
Predicted membrane proteins
Transporters

Predicted localization

 Membrane

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the plasma membrane.

RNA cell category

 Group enriched (REH, CAPAN-2)

Protein evidence

 Evidence at protein level

Main location

 Localized to the Plasma membrane (approved)

DATA RELIABILITY

Reliability score

 Approved based on 1 antibody.
HPA065008
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Group enriched (REH, CAPAN-2)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the plasma membrane.

Main location

 Plasma membrane (approved)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA065008 REH Plasma membrane
HPA065008 SiHa Plasma membrane
HPA065008 U-2 OS Plasma membrane

GENE INFORMATION

Gene name

 AQP5

Synonyms

Description

 Aquaporin 5 (HGNC Symbol)

Entrez gene summary

 Aquaporin 5 (AQP5) is a water channel protein. Aquaporins are a family of small integral membrane proteins related to the major intrinsic protein (MIP or AQP0). Aquaporin 5 plays a role in the generation of saliva, tears and pulmonary secretions. AQP0, AQP2, AQP5, and AQP6 are closely related and all map to 12q13. [provided by RefSeq, Jul 2008]

Chromosome

 12

Cytoband

 q13.12

Chromosome location (bp)

 49961870 - 49965681

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000161798 (version 83.38)

Entrez gene

 362

UniProt

 P55064 (UniProt - Evidence at protein level)

neXtProt

 NX_P55064

Antibodypedia

 AQP5 antibodies

PROTEIN BROWSER
AQP5-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
AQP5-001
ENSP00000293599
ENST00000293599
P55064 [Direct mapping]
Aquaporin-5
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Transporters
   Transporter channels and pores
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   6TM proteins predicted by MDM
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
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GO:0005215 [transporter activity]
GO:0005515 [protein binding]
GO:0005783 [endoplasmic reticulum]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005902 [microvillus]
GO:0006810 [transport]
GO:0006833 [water transport]
GO:0007588 [excretion]
GO:0009925 [basal plasma membrane]
GO:0009992 [cellular water homeostasis]
GO:0015250 [water channel activity]
GO:0015254 [glycerol channel activity]
GO:0015670 [carbon dioxide transport]
GO:0015793 [glycerol transport]
GO:0016020 [membrane]
GO:0016324 [apical plasma membrane]
GO:0030157 [pancreatic juice secretion]
GO:0034220 [ion transmembrane transport]
GO:0042476 [odontogenesis]
GO:0046541 [saliva secretion]
GO:0048593 [camera-type eye morphogenesis]
GO:0055085 [transmembrane transport]
GO:0070062 [extracellular exosome]
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 265 aa
28.3 kDa 		No 6

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.