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AQP5

GENERAL INFORMATION

Gene name

 AQP5

Gene description

 Aquaporin 5

Protein class

 Disease related genes
Potential drug targets
Predicted membrane proteins
Transporters

Predicted localization

 Membrane

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enhanced (endometrial cancer)
HPA (cell line):Group enriched (CAPAN-2, REH)
HPA (normal tissue):Group enriched (salivary gland, stomach, testis)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Membranous expression mainly in salivary gland and testis.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data. Protein expression in respiratory epithelia can be correlated with lung RNA-seq data.

Reliability score

 Supported based on 1 antibody.
HPA065008
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PROGNOSTIC SUMMARY
Prognostic marker in head and neck cancer (favourable).
Head and neck cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enhanced (endometrial cancer)

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Endometrial cancer

STAINING SUMMARY
HPA065008

GENE INFORMATION

Gene name

 AQP5

Synonyms

Description

 Aquaporin 5 (HGNC Symbol)

Entrez gene summary

 Aquaporin 5 (AQP5) is a water channel protein. Aquaporins are a family of small integral membrane proteins related to the major intrinsic protein (MIP or AQP0). Aquaporin 5 plays a role in the generation of saliva, tears and pulmonary secretions. AQP0, AQP2, AQP5, and AQP6 are closely related and all map to 12q13. [provided by RefSeq, Jul 2008]

Chromosome

 12

Cytoband

 q13.12

Chromosome location (bp)

 49961870 - 49965681

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000161798 (version 83.38)

Entrez gene

 362

UniProt

 P55064 (UniProt - Evidence at protein level)

neXtProt

 NX_P55064

Antibodypedia

 AQP5 antibodies

PROTEIN BROWSER
AQP5-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
AQP5-001
ENSP00000293599
ENST00000293599
P55064 [Direct mapping]
Aquaporin-5
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Transporters
   Transporter channels and pores
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   6TM proteins predicted by MDM
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
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GO:0005215 [transporter activity]
GO:0005515 [protein binding]
GO:0005783 [endoplasmic reticulum]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005902 [microvillus]
GO:0006810 [transport]
GO:0006833 [water transport]
GO:0007588 [excretion]
GO:0009925 [basal plasma membrane]
GO:0009992 [cellular water homeostasis]
GO:0015250 [water channel activity]
GO:0015254 [glycerol channel activity]
GO:0015670 [carbon dioxide transport]
GO:0015793 [glycerol transport]
GO:0016020 [membrane]
GO:0016324 [apical plasma membrane]
GO:0030157 [pancreatic juice secretion]
GO:0034220 [ion transmembrane transport]
GO:0042476 [odontogenesis]
GO:0046541 [saliva secretion]
GO:0048593 [camera-type eye morphogenesis]
GO:0055085 [transmembrane transport]
GO:0070062 [extracellular exosome]
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 265 aa
28.3 kDa 		No 6

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.