Expression of GRASP in cancer - Summary - The Human Protein Atlas

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GRASP

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	GRASP
Gene description	GRP1 (general receptor for phosphoinositides 1)-associated scaffold protein
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (HUVEC TERT2, TIME, WM-115)
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General cytoplasmic expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA040664
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA040664

GENE INFORMATION
Gene name	GRASP (HGNC Symbol)
Synonyms	Tamalin
Description	GRP1 (general receptor for phosphoinositides 1)-associated scaffold protein (HGNC Symbol)
Entrez gene summary	This gene encodes a protein that functions as a molecular scaffold, linking receptors, including group 1 metabotropic glutamate receptors, to neuronal proteins. The encoded protein contains conserved domains, including a leucine zipper sequence, PDZ domain and a C-terminal PDZ-binding motif. Alternately spliced transcript variants have been observed for this gene.[provided by RefSeq, Dec 2012]
Chromosome	12
Cytoband	q13.13
Chromosome location (bp)	52006940 - 52015889
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000161835 (version 83.38)
Entrez gene	160622
UniProt	Q7Z6J2 (UniProt - Evidence at protein level)
neXtProt	NX_Q7Z6J2
Antibodypedia	GRASP antibodies

PROTEIN BROWSER

GRASP-001	GRASP-003	GRASP-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GRASP-001 ENSP00000293662 ENST00000293662	Q7Z6J2 [Direct mapping] General receptor for phosphoinositides 1-associated scaffold protein Show all	Predicted intracellular proteins Show all	GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0007165 [signal transduction] GO:0008104 [protein localization] GO:0030054 [cell junction] GO:0030165 [PDZ domain binding] GO:0030306 [ADP-ribosylation factor binding] GO:0042802 [identical protein binding] GO:0045211 [postsynaptic membrane] GO:0048471 [perinuclear region of cytoplasm] Show all	395 aa 42.6 kDa	No	0
GRASP-003 ENSP00000449492 ENST00000552049	Q7Z6J2 [Direct mapping] General receptor for phosphoinositides 1-associated scaffold protein Show all	Predicted intracellular proteins Show all	GO:0005515 [protein binding] GO:0030054 [cell junction] GO:0045211 [postsynaptic membrane] GO:0048471 [perinuclear region of cytoplasm] Show all	252 aa 26.9 kDa	No	0
GRASP-005 ENSP00000448476 ENST00000546756	F8VRX5 [Direct mapping] General receptor for phosphoinositides 1-associated scaffold protein Show all	Predicted intracellular proteins Show all	GO:0005515 [protein binding] Show all	221 aa 23.1 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.