Expression of SPC24 in cancer - Summary - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

SPC24

TISSUE

premium

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	SPC24
Gene description	SPC24, NDC80 kinetochore complex component
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	6
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Mixed
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Nuclear expression in a few tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA051234
	SHOW MORE

PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable), pancreatic cancer (unfavourable), liver cancer (unfavourable) and cervical cancer (favourable).
Renal cancer p<0.001 Pancreatic cancer p<0.001 Liver cancer p<0.001 Cervical cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA051234

GENE INFORMATION
Gene name	SPC24 (HGNC Symbol)
Synonyms	FLJ90806, SPBC24
Description	SPC24, NDC80 kinetochore complex component (HGNC Symbol)
Entrez gene summary
Chromosome	19
Cytoband	p13.2
Chromosome location (bp)	11131520 - 11155808
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000161888 (version 83.38)
Entrez gene	147841
UniProt	Q8NBT2 (UniProt - Evidence at protein level)
neXtProt	NX_Q8NBT2
Antibodypedia	SPC24 antibodies

PROTEIN BROWSER

SPC24-001	SPC24-004	SPC24-005	SPC24-006	SPC24-007	SPC24-008

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SPC24-001 ENSP00000465075 ENST00000592540	Q8NBT2 [Direct mapping] Kinetochore protein Spc24 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000278 [mitotic cell cycle] GO:0000777 [condensed chromosome kinetochore] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005730 [nucleolus] GO:0005829 [cytosol] GO:0007067 [mitotic nuclear division] GO:0007264 [small GTPase mediated signal transduction] GO:0031262 [Ndc80 complex] GO:0051301 [cell division] Show all	197 aa 22.4 kDa	No	0
SPC24-004 ENSP00000465167 ENST00000585486	K7EJH0 [Direct mapping] Kinetochore protein Spc24 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		168 aa 19 kDa	No	0
SPC24-005 ENSP00000465335 ENST00000592967	K7EJV2 [Direct mapping] Kinetochore protein Spc24 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		172 aa 19.5 kDa	No	0
SPC24-006 ENSP00000466688 ENST00000591396	K7EMX1 [Direct mapping] Kinetochore protein Spc24 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		171 aa 19.4 kDa	No	0
SPC24-007 ENSP00000468366 ENST00000586708	K7ERQ7 [Direct mapping] Kinetochore protein Spc24 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		126 aa 13.6 kDa	No	0
SPC24-008 ENSP00000468818 ENST00000585567	K7ESQ2 [Direct mapping] Kinetochore protein Spc24 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		209 aa 23.5 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.