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ALOX15

GENERAL INFORMATION

Gene name

 ALOX15

Gene description

 Arachidonate 15-lipoxygenase

Protein class

 Disease related genes
Enzymes
Potential drug targets
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Mixed
HPA (cell line):Group enriched (HMC-1, MCF7, T-47d)
HPA (normal tissue):Tissue enhanced (fallopian tube, lung)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in respiratory epithelial cells and subsets of immune cells.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Presumed off target binding observed and disregarded. Antibody staining in cells/structures not annotated, view images. Protein expression in respiratory epithelia can be correlated with lung RNA-seq expression data.

Reliability score

 Approved based on 3 antibodies.
HPA013859 , CAB004962 , CAB004963
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA013859
CAB004962
CAB004963

GENE INFORMATION

Gene name

 ALOX15 (HGNC Symbol)

Synonyms

 15-LOX-1

Description

 Arachidonate 15-lipoxygenase (HGNC Symbol)

Entrez gene summary

Chromosome

 17

Cytoband

 p13.2

Chromosome location (bp)

 4630902 - 4642294

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000161905 (version 83.38)

Entrez gene

 246

UniProt

 P16050 (UniProt - Evidence at protein level)

neXtProt

 NX_P16050

Antibodypedia

 ALOX15 antibodies

PROTEIN BROWSER
ALOX15-001
ALOX15-002
ALOX15-005
ALOX15-008
ALOX15-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ALOX15-001
ENSP00000458832
ENST00000570836
P16050 [Direct mapping]
Arachidonate 15-lipoxygenase
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Enzymes
   ENZYME proteins
   Oxidoreductases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001503 [ossification]
GO:0002820 [negative regulation of adaptive immune response]
GO:0004052 [arachidonate 12-lipoxygenase activity]
GO:0005506 [iron ion binding]
GO:0005515 [protein binding]
GO:0005546 [phosphatidylinositol-4,5-bisphosphate binding]
GO:0005737 [cytoplasm]
GO:0005811 [lipid particle]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006646 [phosphatidylethanolamine biosynthetic process]
GO:0006691 [leukotriene metabolic process]
GO:0006954 [inflammatory response]
GO:0010811 [positive regulation of cell-substrate adhesion]
GO:0016020 [membrane]
GO:0016702 [oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen]
GO:0019369 [arachidonic acid metabolic process]
GO:0019372 [lipoxygenase pathway]
GO:0030282 [bone mineralization]
GO:0030838 [positive regulation of actin filament polymerization]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0034116 [positive regulation of heterotypic cell-cell adhesion]
GO:0034976 [response to endoplasmic reticulum stress]
GO:0035358 [regulation of peroxisome proliferator activated receptor signaling pathway]
GO:0035963 [cellular response to interleukin-13]
GO:0042060 [wound healing]
GO:0043277 [apoptotic cell clearance]
GO:0044281 [small molecule metabolic process]
GO:0046872 [metal ion binding]
GO:0047977 [hepoxilin-epoxide hydrolase activity]
GO:0050473 [arachidonate 15-lipoxygenase activity]
GO:0051120 [hepoxilin A3 synthase activity]
GO:0051122 [hepoxilin biosynthetic process]
GO:0055114 [oxidation-reduction process]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0071277 [cellular response to calcium ion]
GO:0097260 [eoxin A4 synthase activity]
GO:1901074 [regulation of engulfment of apoptotic cell]
GO:2001303 [lipoxin A4 biosynthetic process]
Show all
 662 aa
74.8 kDa 		No 0
ALOX15-002
ENSP00000460483
ENST00000574640
P16050 [Direct mapping]
Arachidonate 15-lipoxygenase
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001503 [ossification]
GO:0002820 [negative regulation of adaptive immune response]
GO:0004052 [arachidonate 12-lipoxygenase activity]
GO:0005506 [iron ion binding]
GO:0005515 [protein binding]
GO:0005546 [phosphatidylinositol-4,5-bisphosphate binding]
GO:0005811 [lipid particle]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006646 [phosphatidylethanolamine biosynthetic process]
GO:0006691 [leukotriene metabolic process]
GO:0006954 [inflammatory response]
GO:0010811 [positive regulation of cell-substrate adhesion]
GO:0016020 [membrane]
GO:0016702 [oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen]
GO:0019369 [arachidonic acid metabolic process]
GO:0019372 [lipoxygenase pathway]
GO:0030282 [bone mineralization]
GO:0030838 [positive regulation of actin filament polymerization]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0034976 [response to endoplasmic reticulum stress]
GO:0035358 [regulation of peroxisome proliferator activated receptor signaling pathway]
GO:0035963 [cellular response to interleukin-13]
GO:0042060 [wound healing]
GO:0043277 [apoptotic cell clearance]
GO:0044281 [small molecule metabolic process]
GO:0046872 [metal ion binding]
GO:0050473 [arachidonate 15-lipoxygenase activity]
GO:0051122 [hepoxilin biosynthetic process]
GO:0055114 [oxidation-reduction process]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0071277 [cellular response to calcium ion]
GO:0097260 [eoxin A4 synthase activity]
GO:1901074 [regulation of engulfment of apoptotic cell]
GO:2001303 [lipoxin A4 biosynthetic process]
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 623 aa
70.1 kDa 		No 0
ALOX15-005
ENSP00000460430
ENST00000572265
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 4 aa
0.3 kDa 		No 0
ALOX15-008
ENSP00000458630
ENST00000576394
I3L175 [Direct mapping]
Arachidonate 15-lipoxygenase
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005506 [iron ion binding]
GO:0005515 [protein binding]
GO:0016702 [oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen]
GO:0055114 [oxidation-reduction process]
Show all
 109 aa
12.3 kDa 		No 0
ALOX15-201
ENSP00000293761
ENST00000293761
P16050 [Direct mapping]
Arachidonate 15-lipoxygenase
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001503 [ossification]
GO:0002820 [negative regulation of adaptive immune response]
GO:0004052 [arachidonate 12-lipoxygenase activity]
GO:0005506 [iron ion binding]
GO:0005515 [protein binding]
GO:0005546 [phosphatidylinositol-4,5-bisphosphate binding]
GO:0005811 [lipid particle]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006646 [phosphatidylethanolamine biosynthetic process]
GO:0006691 [leukotriene metabolic process]
GO:0006954 [inflammatory response]
GO:0010811 [positive regulation of cell-substrate adhesion]
GO:0016020 [membrane]
GO:0016702 [oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen]
GO:0019369 [arachidonic acid metabolic process]
GO:0019372 [lipoxygenase pathway]
GO:0030282 [bone mineralization]
GO:0030838 [positive regulation of actin filament polymerization]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0034976 [response to endoplasmic reticulum stress]
GO:0035358 [regulation of peroxisome proliferator activated receptor signaling pathway]
GO:0035963 [cellular response to interleukin-13]
GO:0042060 [wound healing]
GO:0043277 [apoptotic cell clearance]
GO:0044281 [small molecule metabolic process]
GO:0046872 [metal ion binding]
GO:0050473 [arachidonate 15-lipoxygenase activity]
GO:0051122 [hepoxilin biosynthetic process]
GO:0055114 [oxidation-reduction process]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0071277 [cellular response to calcium ion]
GO:0097260 [eoxin A4 synthase activity]
GO:1901074 [regulation of engulfment of apoptotic cell]
GO:2001303 [lipoxin A4 biosynthetic process]
Show all
 662 aa
74.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.