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EIF4A1

GENERAL INFORMATION

Gene name

 EIF4A1

Gene description

 Eukaryotic translation initiation factor 4A1

Protein class

 Enzymes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 14
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in several tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Pending external verification.

Reliability score

 Uncertain based on 1 antibody.
CAB011689
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 EIF4A1 (HGNC Symbol)

Synonyms

 DDX2A, EIF-4A, EIF4A

Description

 Eukaryotic translation initiation factor 4A1 (HGNC Symbol)

Entrez gene summary

Chromosome

 17

Cytoband

 p13.1

Chromosome location (bp)

 7572706 - 7579005

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000161960 (version 83.38)

Entrez gene

 1973

UniProt

 P60842 (UniProt - Evidence at protein level)

neXtProt

 NX_P60842

Antibodypedia

 EIF4A1 antibodies

PROTEIN BROWSER
«
EIF4A1-001
EIF4A1-007
EIF4A1-008
EIF4A1-015
EIF4A1-017
EIF4A1-018
EIF4A1-022
EIF4A1-023
EIF4A1-024
EIF4A1-025
EIF4A1-026
EIF4A1-028
EIF4A1-031
EIF4A1-037
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
EIF4A1-001
ENSP00000293831
ENST00000293831
P60842 [Direct mapping]
Eukaryotic initiation factor 4A-I
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000288 [nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay]
GO:0000289 [nuclear-transcribed mRNA poly(A) tail shortening]
GO:0000339 [RNA cap binding]
GO:0003676 [nucleic acid binding]
GO:0003725 [double-stranded RNA binding]
GO:0003729 [mRNA binding]
GO:0003743 [translation initiation factor activity]
GO:0004004 [ATP-dependent RNA helicase activity]
GO:0004386 [helicase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006412 [translation]
GO:0006413 [translational initiation]
GO:0006446 [regulation of translational initiation]
GO:0008135 [translation factor activity, RNA binding]
GO:0010467 [gene expression]
GO:0010468 [regulation of gene expression]
GO:0010501 [RNA secondary structure unwinding]
GO:0016020 [membrane]
GO:0016032 [viral process]
GO:0016281 [eukaryotic translation initiation factor 4F complex]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0031100 [organ regeneration]
GO:0044267 [cellular protein metabolic process]
GO:0044822 [poly(A) RNA binding]
GO:0070062 [extracellular exosome]
Show all
 406 aa
46.2 kDa 		No 0
EIF4A1-007
ENSP00000463486
ENST00000577269
P60842 [Direct mapping]
Eukaryotic initiation factor 4A-I
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000288 [nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay]
GO:0000289 [nuclear-transcribed mRNA poly(A) tail shortening]
GO:0000339 [RNA cap binding]
GO:0003676 [nucleic acid binding]
GO:0003725 [double-stranded RNA binding]
GO:0003729 [mRNA binding]
GO:0003743 [translation initiation factor activity]
GO:0004004 [ATP-dependent RNA helicase activity]
GO:0004386 [helicase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006412 [translation]
GO:0006413 [translational initiation]
GO:0006446 [regulation of translational initiation]
GO:0008135 [translation factor activity, RNA binding]
GO:0010467 [gene expression]
GO:0010468 [regulation of gene expression]
GO:0010501 [RNA secondary structure unwinding]
GO:0016020 [membrane]
GO:0016032 [viral process]
GO:0016281 [eukaryotic translation initiation factor 4F complex]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0044267 [cellular protein metabolic process]
GO:0044822 [poly(A) RNA binding]
GO:0070062 [extracellular exosome]
Show all
 347 aa
39.5 kDa 		No 0
EIF4A1-008
ENSP00000462753
ENST00000582746
J3KT12 [Direct mapping]
Eukaryotic initiation factor 4A-I
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003676 [nucleic acid binding]
GO:0004004 [ATP-dependent RNA helicase activity]
GO:0005524 [ATP binding]
GO:0006413 [translational initiation]
GO:0006446 [regulation of translational initiation]
GO:0010468 [regulation of gene expression]
GO:0010501 [RNA secondary structure unwinding]
Show all
 341 aa
38.9 kDa 		No 0
EIF4A1-015
ENSP00000462741
ENST00000581770
J3KT04 [Direct mapping]
Eukaryotic initiation factor 4A-I
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004004 [ATP-dependent RNA helicase activity]
GO:0006413 [translational initiation]
GO:0006446 [regulation of translational initiation]
GO:0010468 [regulation of gene expression]
GO:0010501 [RNA secondary structure unwinding]
Show all
 85 aa
9.3 kDa 		No 0
EIF4A1-017
ENSP00000462904
ENST00000584860
J3KTB5 [Direct mapping]
Eukaryotic initiation factor 4A-I
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003676 [nucleic acid binding]
GO:0004004 [ATP-dependent RNA helicase activity]
GO:0005524 [ATP binding]
GO:0006413 [translational initiation]
GO:0006446 [regulation of translational initiation]
GO:0010468 [regulation of gene expression]
GO:0010501 [RNA secondary structure unwinding]
Show all
 257 aa
29.1 kDa 		No 0
EIF4A1-018
ENSP00000462372
ENST00000577929
J3KS93 [Direct mapping]
Eukaryotic initiation factor 4A-I
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003676 [nucleic acid binding]
GO:0004004 [ATP-dependent RNA helicase activity]
GO:0005524 [ATP binding]
GO:0006413 [translational initiation]
GO:0006446 [regulation of translational initiation]
GO:0010468 [regulation of gene expression]
GO:0010501 [RNA secondary structure unwinding]
Show all
 85 aa
9.4 kDa 		No 0
EIF4A1-022
ENSP00000463634
ENST00000583802
J3QLN6 [Direct mapping]
Eukaryotic initiation factor 4A-I
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003676 [nucleic acid binding]
GO:0004004 [ATP-dependent RNA helicase activity]
GO:0005524 [ATP binding]
GO:0006413 [translational initiation]
GO:0006446 [regulation of translational initiation]
GO:0010468 [regulation of gene expression]
GO:0010501 [RNA secondary structure unwinding]
Show all
 163 aa
18 kDa 		No 0
EIF4A1-023
ENSP00000463067
ENST00000578754
J3KTN0 [Direct mapping]
Eukaryotic initiation factor 4A-I
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003676 [nucleic acid binding]
GO:0004004 [ATP-dependent RNA helicase activity]
GO:0005524 [ATP binding]
GO:0006413 [translational initiation]
GO:0006446 [regulation of translational initiation]
GO:0010468 [regulation of gene expression]
GO:0010501 [RNA secondary structure unwinding]
Show all
 117 aa
13.9 kDa 		No 0
EIF4A1-024
ENSP00000463309
ENST00000582169
J3QKZ9 [Direct mapping]
Eukaryotic initiation factor 4A-I
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003676 [nucleic acid binding]
GO:0004004 [ATP-dependent RNA helicase activity]
GO:0005524 [ATP binding]
GO:0006413 [translational initiation]
GO:0006446 [regulation of translational initiation]
GO:0010468 [regulation of gene expression]
GO:0010501 [RNA secondary structure unwinding]
Show all
 135 aa
14.7 kDa 		No 0
EIF4A1-025
ENSP00000462275
ENST00000585024
J3KS25 [Direct mapping]
Eukaryotic initiation factor 4A-I
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003676 [nucleic acid binding]
GO:0004004 [ATP-dependent RNA helicase activity]
GO:0005524 [ATP binding]
GO:0006413 [translational initiation]
GO:0006446 [regulation of translational initiation]
GO:0010468 [regulation of gene expression]
GO:0010501 [RNA secondary structure unwinding]
Show all
 188 aa
20.7 kDa 		No 0
EIF4A1-026
ENSP00000464550
ENST00000578495
J3QS69 [Direct mapping]
Eukaryotic initiation factor 4A-I
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003676 [nucleic acid binding]
GO:0004004 [ATP-dependent RNA helicase activity]
GO:0005524 [ATP binding]
GO:0006413 [translational initiation]
GO:0006446 [regulation of translational initiation]
GO:0010468 [regulation of gene expression]
GO:0010501 [RNA secondary structure unwinding]
Show all
 300 aa
33.9 kDa 		No 0
EIF4A1-028
ENSP00000463366
ENST00000584784
J3QL43 [Direct mapping]
Eukaryotic initiation factor 4A-I
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003676 [nucleic acid binding]
GO:0004004 [ATP-dependent RNA helicase activity]
GO:0005524 [ATP binding]
GO:0006413 [translational initiation]
GO:0006446 [regulation of translational initiation]
GO:0010468 [regulation of gene expression]
GO:0010501 [RNA secondary structure unwinding]
Show all
 271 aa
30.6 kDa 		No 0
EIF4A1-031
ENSP00000462719
ENST00000583389
J3KSZ0 [Direct mapping]
Eukaryotic initiation factor 4A-I
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003676 [nucleic acid binding]
GO:0004004 [ATP-dependent RNA helicase activity]
GO:0005524 [ATP binding]
GO:0006413 [translational initiation]
GO:0006446 [regulation of translational initiation]
GO:0010468 [regulation of gene expression]
GO:0010501 [RNA secondary structure unwinding]
Show all
 230 aa
26.7 kDa 		No 0
EIF4A1-037
ENSP00000464066
ENST00000581384
J3QR64 [Direct mapping]
Eukaryotic initiation factor 4A-I
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003676 [nucleic acid binding]
GO:0004004 [ATP-dependent RNA helicase activity]
GO:0005524 [ATP binding]
GO:0006413 [translational initiation]
GO:0006446 [regulation of translational initiation]
GO:0010468 [regulation of gene expression]
GO:0010501 [RNA secondary structure unwinding]
Show all
 214 aa
23.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.