Fields »
ABOUT
HELP
BLOG
CCNF

Please wait until image is loaded before changing channels

GENERAL INFORMATION

Gene name

 CCNF

Gene description

 Cyclin F

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the centrosome.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Centrosome (supported)

DATA RELIABILITY

Reliability score

 Supported based on 1 antibody.
HPA060596
SHOW MORE

ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the centrosome.

Main location

 Centrosome (supported)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA060596 CACO-2 Cell Junctions
Centrosome
HPA060596 MCF7 Centrosome

GENE INFORMATION

Gene name

 CCNF (HGNC Symbol)

Synonyms

 FBX1, FBXO1

Description

 Cyclin F (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the cyclin family. Cyclins are important regulators of cell cycle transitions through their ability to bind and activate cyclin-dependent protein kinases. This member also belongs to the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and it was one of the first proteins in which the F-box motif was identified. [provided by RefSeq, Jul 2008]

Chromosome

 16

Cytoband

 p13.3

Chromosome location (bp)

 2429394 - 2458854

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000162063 (version 83.38)

Entrez gene

 899

UniProt

 P41002 (UniProt - Evidence at protein level)

neXtProt

 NX_P41002

Antibodypedia

 CCNF antibodies

PROTEIN BROWSER
CCNF-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CCNF-001
ENSP00000380256
ENST00000397066
P41002 [Direct mapping]
Cyclin-F
Show all
   Phobius predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000320 [re-entry into mitotic cell cycle]
GO:0001890 [placenta development]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005814 [centriole]
GO:0007067 [mitotic nuclear division]
GO:0010826 [negative regulation of centrosome duplication]
GO:0016567 [protein ubiquitination]
GO:0019005 [SCF ubiquitin ligase complex]
GO:0031146 [SCF-dependent proteasomal ubiquitin-dependent protein catabolic process]
GO:0051301 [cell division]
Show all
 786 aa
87.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.