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CCNF

GENERAL INFORMATION

Gene name

 CCNF

Gene description

 Cyclin F

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in subsets of immune cells in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA070495 , HPA071600
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable).
Liver cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA070495
HPA071600

GENE INFORMATION

Gene name

 CCNF (HGNC Symbol)

Synonyms

 FBX1, FBXO1

Description

 Cyclin F (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the cyclin family. Cyclins are important regulators of cell cycle transitions through their ability to bind and activate cyclin-dependent protein kinases. This member also belongs to the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and it was one of the first proteins in which the F-box motif was identified. [provided by RefSeq, Jul 2008]

Chromosome

 16

Cytoband

 p13.3

Chromosome location (bp)

 2429394 - 2458854

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000162063 (version 83.38)

Entrez gene

 899

UniProt

 P41002 (UniProt - Evidence at protein level)

neXtProt

 NX_P41002

Antibodypedia

 CCNF antibodies

PROTEIN BROWSER
CCNF-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CCNF-001
ENSP00000380256
ENST00000397066
P41002 [Direct mapping]
Cyclin-F
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   Phobius predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0000320 [re-entry into mitotic cell cycle]
GO:0001890 [placenta development]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005814 [centriole]
GO:0007067 [mitotic nuclear division]
GO:0010826 [negative regulation of centrosome duplication]
GO:0016567 [protein ubiquitination]
GO:0019005 [SCF ubiquitin ligase complex]
GO:0031146 [SCF-dependent proteasomal ubiquitin-dependent protein catabolic process]
GO:0051301 [cell division]
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 786 aa
87.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.