Expression of AMDHD2 in cancer - Summary - The Human Protein Atlas

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AMDHD2

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	AMDHD2
Gene description	Amidohydrolase domain containing 2
Protein class	Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Mixed
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in several tissues at variable levels.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 2 antibodies. HPA041184 , HPA041321
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PROGNOSTIC SUMMARY
Prognostic marker in cervical cancer (favourable).
Cervical cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA041184	HPA041321

GENE INFORMATION
Gene name	AMDHD2 (HGNC Symbol)
Synonyms	CGI-14
Description	Amidohydrolase domain containing 2 (HGNC Symbol)
Entrez gene summary
Chromosome	16
Cytoband	p13.3
Chromosome location (bp)	2520357 - 2531422
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000162066 (version 83.38)
Entrez gene	51005
UniProt	Q9Y303 (UniProt - Evidence at protein level)
neXtProt	NX_Q9Y303
Antibodypedia	AMDHD2 antibodies

PROTEIN BROWSER

AMDHD2-001	AMDHD2-002	AMDHD2-003	AMDHD2-004	AMDHD2-011	AMDHD2-012	AMDHD2-013

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
AMDHD2-001 ENSP00000307481 ENST00000302956	Q9Y303 [Direct mapping] Putative N-acetylglucosamine-6-phosphate deacetylase Show all	Enzymes ENZYME proteins Hydrolases SCAMPI predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005975 [carbohydrate metabolic process] GO:0006044 [N-acetylglucosamine metabolic process] GO:0006046 [N-acetylglucosamine catabolic process] GO:0008448 [N-acetylglucosamine-6-phosphate deacetylase activity] GO:0016787 [hydrolase activity] GO:0016810 [hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds] GO:0019262 [N-acetylneuraminate catabolic process] GO:0046872 [metal ion binding] Show all	439 aa 46.9 kDa	No	0
AMDHD2-002 ENSP00000457136 ENST00000568263	H3BTE3 [Direct mapping] Putative N-acetylglucosamine-6-phosphate deacetylase Show all	SCAMPI predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008152 [metabolic process] GO:0016787 [hydrolase activity] GO:0016810 [hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds] Show all	269 aa 28.5 kDa	No	0
AMDHD2-003 ENSP00000391596 ENST00000413459	Q9Y303 [Direct mapping] Putative N-acetylglucosamine-6-phosphate deacetylase Show all	Enzymes ENZYME proteins Hydrolases SCAMPI predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005975 [carbohydrate metabolic process] GO:0006046 [N-acetylglucosamine catabolic process] GO:0008448 [N-acetylglucosamine-6-phosphate deacetylase activity] GO:0016787 [hydrolase activity] GO:0016810 [hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds] GO:0019262 [N-acetylneuraminate catabolic process] GO:0046872 [metal ion binding] Show all	594 aa 63.6 kDa	No	0
AMDHD2-004 ENSP00000293971 ENST00000293971	Q9Y303 [Direct mapping] Putative N-acetylglucosamine-6-phosphate deacetylase Show all	Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005975 [carbohydrate metabolic process] GO:0006044 [N-acetylglucosamine metabolic process] GO:0006046 [N-acetylglucosamine catabolic process] GO:0008448 [N-acetylglucosamine-6-phosphate deacetylase activity] GO:0016810 [hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds] GO:0019262 [N-acetylneuraminate catabolic process] GO:0046872 [metal ion binding] Show all	409 aa 43.7 kDa	No	0
AMDHD2-011 ENSP00000456898 ENST00000566706	H3BSV9 [Direct mapping] Putative N-acetylglucosamine-6-phosphate deacetylase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008152 [metabolic process] GO:0016810 [hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds] Show all	300 aa 31.9 kDa	No	0
AMDHD2-012 ENSP00000457398 ENST00000569879	H3BTZ6 [Direct mapping] Putative N-acetylglucosamine-6-phosphate deacetylase Show all	SCAMPI predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008152 [metabolic process] GO:0016810 [hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds] Show all	296 aa 31.5 kDa	No	0
AMDHD2-013 ENSP00000456656 ENST00000563556	H3BSD5 [Direct mapping] Putative N-acetylglucosamine-6-phosphate deacetylase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008152 [metabolic process] GO:0016810 [hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds] Show all	156 aa 16.9 kDa	No	0

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The Human Protein Atlas

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