Expression of TTC9C in cancer - Summary - The Human Protein Atlas

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TTC9C

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	TTC9C
Gene description	Tetratricopeptide repeat domain 9C
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in all tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA055169
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable) and stomach cancer (favourable).
Renal cancer p<0.001 Stomach cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA055169

GENE INFORMATION
Gene name	TTC9C (HGNC Symbol)
Synonyms	MGC29649
Description	Tetratricopeptide repeat domain 9C (HGNC Symbol)
Entrez gene summary
Chromosome	11
Cytoband	q12.3
Chromosome location (bp)	62728069 - 62740293
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000162222 (version 83.38)
Entrez gene	283237
UniProt	Q8N5M4 (UniProt - Evidence at protein level)
neXtProt	NX_Q8N5M4
Antibodypedia	TTC9C antibodies

PROTEIN BROWSER

TTC9C-001	TTC9C-002	TTC9C-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TTC9C-001 ENSP00000325266 ENST00000316461	Q8N5M4 [Direct mapping] Tetratricopeptide repeat protein 9C Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000413 [protein peptidyl-prolyl isomerization] GO:0003755 [peptidyl-prolyl cis-trans isomerase activity] GO:0005515 [protein binding] GO:0005528 [FK506 binding] GO:0005737 [cytoplasm] GO:0005789 [endoplasmic reticulum membrane] GO:0061077 [chaperone-mediated protein folding] Show all	171 aa 20 kDa	No	0
TTC9C-002 ENSP00000434340 ENST00000532583	Q8N5M4 [Direct mapping] Tetratricopeptide repeat protein 9C Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000413 [protein peptidyl-prolyl isomerization] GO:0003755 [peptidyl-prolyl cis-trans isomerase activity] GO:0005515 [protein binding] GO:0005528 [FK506 binding] GO:0005737 [cytoplasm] GO:0005789 [endoplasmic reticulum membrane] GO:0061077 [chaperone-mediated protein folding] Show all	171 aa 20 kDa	No	0
TTC9C-004 ENSP00000435282 ENST00000530625	E9PKV8 [Direct mapping] Tetratricopeptide repeat protein 9C Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000413 [protein peptidyl-prolyl isomerization] GO:0003755 [peptidyl-prolyl cis-trans isomerase activity] GO:0005515 [protein binding] GO:0005528 [FK506 binding] GO:0005737 [cytoplasm] GO:0005789 [endoplasmic reticulum membrane] GO:0061077 [chaperone-mediated protein folding] Show all	140 aa 16.3 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.