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SYVN1

GENERAL INFORMATION

Gene name

 SYVN1

Gene description

 Synovial apoptosis inhibitor 1, synoviolin

Protein class

 Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in most tissues. Highly abundant in a subset of immune cells.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 3 antibodies.
HPA005480 , HPA024300 , CAB037030
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PROGNOSTIC SUMMARY
Prognostic marker in head and neck cancer (favourable).
Head and neck cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA005480
HPA024300
CAB037030

GENE INFORMATION

Gene name

 SYVN1 (HGNC Symbol)

Synonyms

 DER3, HRD1

Description

 Synovial apoptosis inhibitor 1, synoviolin (HGNC Symbol)

Entrez gene summary

 This gene encodes a protein involved in endoplasmic reticulum (ER)-associated degradation. The encoded protein removes unfolded proteins, accumulated during ER stress, by retrograde transport to the cytosol from the ER. This protein also uses the ubiquitin-proteasome system for additional degradation of unfolded proteins. Sequence analysis identified two transcript variants that encode different isoforms. [provided by RefSeq, May 2011]

Chromosome

 11

Cytoband

 q13.1

Chromosome location (bp)

 65121780 - 65134533

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000162298 (version 83.38)

Entrez gene

 84447

UniProt

 Q86TM6 (UniProt - Evidence at protein level)

neXtProt

 NX_Q86TM6

Antibodypedia

 SYVN1 antibodies

PROTEIN BROWSER
SYVN1-001
SYVN1-002
SYVN1-004
SYVN1-005
SYVN1-007
SYVN1-011

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SYVN1-001
ENSP00000366395
ENST00000377190
Q86TM6 [Direct mapping]
E3 ubiquitin-protein ligase synoviolin
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   5TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000836 [Hrd1p ubiquitin ligase complex]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005790 [smooth endoplasmic reticulum]
GO:0006457 [protein folding]
GO:0008270 [zinc ion binding]
GO:0016020 [membrane]
GO:0016567 [protein ubiquitination]
GO:0016874 [ligase activity]
GO:0018279 [protein N-linked glycosylation via asparagine]
GO:0030176 [integral component of endoplasmic reticulum membrane]
GO:0030433 [ER-associated ubiquitin-dependent protein catabolic process]
GO:0030968 [endoplasmic reticulum unfolded protein response]
GO:0030970 [retrograde protein transport, ER to cytosol]
GO:0036498 [IRE1-mediated unfolded protein response]
GO:0036503 [ERAD pathway]
GO:0036513 [Derlin-1 retrotranslocation complex]
GO:0042787 [protein ubiquitination involved in ubiquitin-dependent protein catabolic process]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0044322 [endoplasmic reticulum quality control compartment]
GO:0050821 [protein stabilization]
GO:0051082 [unfolded protein binding]
GO:0051087 [chaperone binding]
GO:0051117 [ATPase binding]
GO:0061630 [ubiquitin protein ligase activity]
GO:0070936 [protein K48-linked ubiquitination]
GO:1902236 [negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway]
GO:1904264 [ubiquitin protein ligase activity involved in ERAD pathway]
GO:1990381 [ubiquitin-specific protease binding]
Show all
 617 aa
67.7 kDa 		Yes 5
SYVN1-002
ENSP00000294256
ENST00000294256
Q86TM6 [Direct mapping]
E3 ubiquitin-protein ligase synoviolin
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   5TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000836 [Hrd1p ubiquitin ligase complex]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005790 [smooth endoplasmic reticulum]
GO:0006457 [protein folding]
GO:0008270 [zinc ion binding]
GO:0016020 [membrane]
GO:0016567 [protein ubiquitination]
GO:0016874 [ligase activity]
GO:0018279 [protein N-linked glycosylation via asparagine]
GO:0030176 [integral component of endoplasmic reticulum membrane]
GO:0030433 [ER-associated ubiquitin-dependent protein catabolic process]
GO:0030968 [endoplasmic reticulum unfolded protein response]
GO:0030970 [retrograde protein transport, ER to cytosol]
GO:0036498 [IRE1-mediated unfolded protein response]
GO:0036503 [ERAD pathway]
GO:0036513 [Derlin-1 retrotranslocation complex]
GO:0042787 [protein ubiquitination involved in ubiquitin-dependent protein catabolic process]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0044322 [endoplasmic reticulum quality control compartment]
GO:0050821 [protein stabilization]
GO:0051082 [unfolded protein binding]
GO:0051087 [chaperone binding]
GO:0051117 [ATPase binding]
GO:0061630 [ubiquitin protein ligase activity]
GO:0070936 [protein K48-linked ubiquitination]
GO:1902236 [negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway]
GO:1904264 [ubiquitin protein ligase activity involved in ERAD pathway]
GO:1990381 [ubiquitin-specific protease binding]
Show all
 616 aa
67.6 kDa 		Yes 5
SYVN1-004
ENSP00000436984
ENST00000526060
Q86TM6 [Direct mapping]
E3 ubiquitin-protein ligase synoviolin
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   5TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000836 [Hrd1p ubiquitin ligase complex]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005790 [smooth endoplasmic reticulum]
GO:0006457 [protein folding]
GO:0008270 [zinc ion binding]
GO:0016020 [membrane]
GO:0016567 [protein ubiquitination]
GO:0016874 [ligase activity]
GO:0018279 [protein N-linked glycosylation via asparagine]
GO:0030176 [integral component of endoplasmic reticulum membrane]
GO:0030433 [ER-associated ubiquitin-dependent protein catabolic process]
GO:0030968 [endoplasmic reticulum unfolded protein response]
GO:0030970 [retrograde protein transport, ER to cytosol]
GO:0036498 [IRE1-mediated unfolded protein response]
GO:0036503 [ERAD pathway]
GO:0036513 [Derlin-1 retrotranslocation complex]
GO:0042787 [protein ubiquitination involved in ubiquitin-dependent protein catabolic process]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0044322 [endoplasmic reticulum quality control compartment]
GO:0050821 [protein stabilization]
GO:0051082 [unfolded protein binding]
GO:0051087 [chaperone binding]
GO:0051117 [ATPase binding]
GO:0061630 [ubiquitin protein ligase activity]
GO:0070936 [protein K48-linked ubiquitination]
GO:1902236 [negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway]
GO:1904264 [ubiquitin protein ligase activity involved in ERAD pathway]
GO:1990381 [ubiquitin-specific protease binding]
Show all
 616 aa
67.6 kDa 		Yes 5
SYVN1-005
ENSP00000431720
ENST00000528487
E9PK19 [Direct mapping]
E3 ubiquitin-protein ligase synoviolin
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   4TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0016021 [integral component of membrane]
Show all
 237 aa
27.6 kDa 		Yes 4
SYVN1-007
ENSP00000431215
ENST00000531018
E9PMA1 [Direct mapping]
E3 ubiquitin-protein ligase synoviolin
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   4TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0016021 [integral component of membrane]
Show all
 236 aa
27.7 kDa 		No 4
SYVN1-011
ENSP00000302035
ENST00000307289
Q86TM6 [Direct mapping]
E3 ubiquitin-protein ligase synoviolin
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   5TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000836 [Hrd1p ubiquitin ligase complex]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005790 [smooth endoplasmic reticulum]
GO:0006457 [protein folding]
GO:0008270 [zinc ion binding]
GO:0016020 [membrane]
GO:0016567 [protein ubiquitination]
GO:0016874 [ligase activity]
GO:0018279 [protein N-linked glycosylation via asparagine]
GO:0030176 [integral component of endoplasmic reticulum membrane]
GO:0030433 [ER-associated ubiquitin-dependent protein catabolic process]
GO:0030968 [endoplasmic reticulum unfolded protein response]
GO:0030970 [retrograde protein transport, ER to cytosol]
GO:0036498 [IRE1-mediated unfolded protein response]
GO:0036503 [ERAD pathway]
GO:0036513 [Derlin-1 retrotranslocation complex]
GO:0042787 [protein ubiquitination involved in ubiquitin-dependent protein catabolic process]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0044322 [endoplasmic reticulum quality control compartment]
GO:0050821 [protein stabilization]
GO:0051082 [unfolded protein binding]
GO:0051087 [chaperone binding]
GO:0051117 [ATPase binding]
GO:0061630 [ubiquitin protein ligase activity]
GO:0070936 [protein K48-linked ubiquitination]
GO:1902236 [negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway]
GO:1904264 [ubiquitin protein ligase activity involved in ERAD pathway]
GO:1990381 [ubiquitin-specific protease binding]
Show all
 565 aa
61.7 kDa 		Yes 5

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.