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SYVN1

GENERAL INFORMATION

Gene name

 SYVN1

Gene description

 Synovial apoptosis inhibitor 1, synoviolin

Protein class

 Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 6
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in most tissues. Highly abundant in a subset of immune cells.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 3 antibodies.
HPA005480 , HPA024300 , CAB037030
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Pancreas

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 SYVN1 (HGNC Symbol)

Synonyms

 DER3, HRD1

Description

 Synovial apoptosis inhibitor 1, synoviolin (HGNC Symbol)

Entrez gene summary

 This gene encodes a protein involved in endoplasmic reticulum (ER)-associated degradation. The encoded protein removes unfolded proteins, accumulated during ER stress, by retrograde transport to the cytosol from the ER. This protein also uses the ubiquitin-proteasome system for additional degradation of unfolded proteins. Sequence analysis identified two transcript variants that encode different isoforms. [provided by RefSeq, May 2011]

Chromosome

 11

Cytoband

 q13.1

Chromosome location (bp)

 65121780 - 65134533

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000162298 (version 83.38)

Entrez gene

 84447

UniProt

 Q86TM6 (UniProt - Evidence at protein level)

neXtProt

 NX_Q86TM6

Antibodypedia

 SYVN1 antibodies

PROTEIN BROWSER
SYVN1-001
SYVN1-002
SYVN1-004
SYVN1-005
SYVN1-007
SYVN1-011

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SYVN1-001
ENSP00000366395
ENST00000377190
Q86TM6 [Direct mapping]
E3 ubiquitin-protein ligase synoviolin
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   5TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000836 [Hrd1p ubiquitin ligase complex]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005790 [smooth endoplasmic reticulum]
GO:0006457 [protein folding]
GO:0008270 [zinc ion binding]
GO:0016020 [membrane]
GO:0016567 [protein ubiquitination]
GO:0016874 [ligase activity]
GO:0018279 [protein N-linked glycosylation via asparagine]
GO:0030176 [integral component of endoplasmic reticulum membrane]
GO:0030433 [ER-associated ubiquitin-dependent protein catabolic process]
GO:0030968 [endoplasmic reticulum unfolded protein response]
GO:0030970 [retrograde protein transport, ER to cytosol]
GO:0036498 [IRE1-mediated unfolded protein response]
GO:0036503 [ERAD pathway]
GO:0036513 [Derlin-1 retrotranslocation complex]
GO:0042787 [protein ubiquitination involved in ubiquitin-dependent protein catabolic process]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0044322 [endoplasmic reticulum quality control compartment]
GO:0050821 [protein stabilization]
GO:0051082 [unfolded protein binding]
GO:0051087 [chaperone binding]
GO:0051117 [ATPase binding]
GO:0061630 [ubiquitin protein ligase activity]
GO:0070936 [protein K48-linked ubiquitination]
GO:1902236 [negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway]
GO:1904264 [ubiquitin protein ligase activity involved in ERAD pathway]
GO:1990381 [ubiquitin-specific protease binding]
Show all
 617 aa
67.7 kDa 		Yes 5
SYVN1-002
ENSP00000294256
ENST00000294256
Q86TM6 [Direct mapping]
E3 ubiquitin-protein ligase synoviolin
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   5TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000836 [Hrd1p ubiquitin ligase complex]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005790 [smooth endoplasmic reticulum]
GO:0006457 [protein folding]
GO:0008270 [zinc ion binding]
GO:0016020 [membrane]
GO:0016567 [protein ubiquitination]
GO:0016874 [ligase activity]
GO:0018279 [protein N-linked glycosylation via asparagine]
GO:0030176 [integral component of endoplasmic reticulum membrane]
GO:0030433 [ER-associated ubiquitin-dependent protein catabolic process]
GO:0030968 [endoplasmic reticulum unfolded protein response]
GO:0030970 [retrograde protein transport, ER to cytosol]
GO:0036498 [IRE1-mediated unfolded protein response]
GO:0036503 [ERAD pathway]
GO:0036513 [Derlin-1 retrotranslocation complex]
GO:0042787 [protein ubiquitination involved in ubiquitin-dependent protein catabolic process]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0044322 [endoplasmic reticulum quality control compartment]
GO:0050821 [protein stabilization]
GO:0051082 [unfolded protein binding]
GO:0051087 [chaperone binding]
GO:0051117 [ATPase binding]
GO:0061630 [ubiquitin protein ligase activity]
GO:0070936 [protein K48-linked ubiquitination]
GO:1902236 [negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway]
GO:1904264 [ubiquitin protein ligase activity involved in ERAD pathway]
GO:1990381 [ubiquitin-specific protease binding]
Show all
 616 aa
67.6 kDa 		Yes 5
SYVN1-004
ENSP00000436984
ENST00000526060
Q86TM6 [Direct mapping]
E3 ubiquitin-protein ligase synoviolin
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   5TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000836 [Hrd1p ubiquitin ligase complex]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005790 [smooth endoplasmic reticulum]
GO:0006457 [protein folding]
GO:0008270 [zinc ion binding]
GO:0016020 [membrane]
GO:0016567 [protein ubiquitination]
GO:0016874 [ligase activity]
GO:0018279 [protein N-linked glycosylation via asparagine]
GO:0030176 [integral component of endoplasmic reticulum membrane]
GO:0030433 [ER-associated ubiquitin-dependent protein catabolic process]
GO:0030968 [endoplasmic reticulum unfolded protein response]
GO:0030970 [retrograde protein transport, ER to cytosol]
GO:0036498 [IRE1-mediated unfolded protein response]
GO:0036503 [ERAD pathway]
GO:0036513 [Derlin-1 retrotranslocation complex]
GO:0042787 [protein ubiquitination involved in ubiquitin-dependent protein catabolic process]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0044322 [endoplasmic reticulum quality control compartment]
GO:0050821 [protein stabilization]
GO:0051082 [unfolded protein binding]
GO:0051087 [chaperone binding]
GO:0051117 [ATPase binding]
GO:0061630 [ubiquitin protein ligase activity]
GO:0070936 [protein K48-linked ubiquitination]
GO:1902236 [negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway]
GO:1904264 [ubiquitin protein ligase activity involved in ERAD pathway]
GO:1990381 [ubiquitin-specific protease binding]
Show all
 616 aa
67.6 kDa 		Yes 5
SYVN1-005
ENSP00000431720
ENST00000528487
E9PK19 [Direct mapping]
E3 ubiquitin-protein ligase synoviolin
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   4TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0016021 [integral component of membrane]
Show all
 237 aa
27.6 kDa 		Yes 4
SYVN1-007
ENSP00000431215
ENST00000531018
E9PMA1 [Direct mapping]
E3 ubiquitin-protein ligase synoviolin
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   4TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0016021 [integral component of membrane]
Show all
 236 aa
27.7 kDa 		No 4
SYVN1-011
ENSP00000302035
ENST00000307289
Q86TM6 [Direct mapping]
E3 ubiquitin-protein ligase synoviolin
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   5TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000836 [Hrd1p ubiquitin ligase complex]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005790 [smooth endoplasmic reticulum]
GO:0006457 [protein folding]
GO:0008270 [zinc ion binding]
GO:0016020 [membrane]
GO:0016567 [protein ubiquitination]
GO:0016874 [ligase activity]
GO:0018279 [protein N-linked glycosylation via asparagine]
GO:0030176 [integral component of endoplasmic reticulum membrane]
GO:0030433 [ER-associated ubiquitin-dependent protein catabolic process]
GO:0030968 [endoplasmic reticulum unfolded protein response]
GO:0030970 [retrograde protein transport, ER to cytosol]
GO:0036498 [IRE1-mediated unfolded protein response]
GO:0036503 [ERAD pathway]
GO:0036513 [Derlin-1 retrotranslocation complex]
GO:0042787 [protein ubiquitination involved in ubiquitin-dependent protein catabolic process]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0044322 [endoplasmic reticulum quality control compartment]
GO:0050821 [protein stabilization]
GO:0051082 [unfolded protein binding]
GO:0051087 [chaperone binding]
GO:0051117 [ATPase binding]
GO:0061630 [ubiquitin protein ligase activity]
GO:0070936 [protein K48-linked ubiquitination]
GO:1902236 [negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway]
GO:1904264 [ubiquitin protein ligase activity involved in ERAD pathway]
GO:1990381 [ubiquitin-specific protease binding]
Show all
 565 aa
61.7 kDa 		Yes 5

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.