Cell atlas - TPCN2 - The Human Protein Atlas

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TPCN2

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TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleoli

Human cell
	Nucleoli

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GENERAL INFORMATION
Gene name	TPCN2
Gene description	Two pore segment channel 2
Protein class	Predicted membrane proteins Transporters Voltage-gated ion channels
Predicted localization	Membrane
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleoli.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoli (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA016561
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleoli.

Main location

Nucleoli (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA016561	A-431	Nucleoli fibrillar center
	HPA016561	U-2 OS	Nucleoli
	HPA016561	U-251 MG	Nucleoli

GENE INFORMATION
Gene name	TPCN2 (HGNC Symbol)
Synonyms	TPC2
Description	Two pore segment channel 2 (HGNC Symbol)
Entrez gene summary	This gene encodes a putative cation-selective ion channel with two repeats of a six-transmembrane-domain. The protein localizes to lysosomal membranes and enables nicotinic acid adenine dinucleotide phosphate (NAADP) -induced calcium ion release from lysosome-related stores. This ubiquitously expressed gene has elevated expression in liver and kidney. Two common nonsynonymous SNPs in this gene strongly associate with blond versus brown hair pigmentation.[provided by RefSeq, Dec 2009]
Chromosome	11
Cytoband	q13.3
Chromosome location (bp)	69048897 - 69090604
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000162341 (version 83.38)
Entrez gene	219931
UniProt	Q8NHX9 (UniProt - Evidence at protein level)
neXtProt	NX_Q8NHX9
Antibodypedia	TPCN2 antibodies

PROTEIN BROWSER

TPCN2-001	TPCN2-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TPCN2-001 ENSP00000294309 ENST00000294309	Q8NHX9 [Direct mapping] Two pore calcium channel protein 2 Show all	Transporters Transporter channels and pores Voltage-gated ion channels CatSper and Two-Pore Channels Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005216 [ion channel activity] GO:0005245 [voltage-gated calcium channel activity] GO:0005515 [protein binding] GO:0005764 [lysosome] GO:0005765 [lysosomal membrane] GO:0005886 [plasma membrane] GO:0006811 [ion transport] GO:0006816 [calcium ion transport] GO:0006874 [cellular calcium ion homeostasis] GO:0006939 [smooth muscle contraction] GO:0007040 [lysosome organization] GO:0010008 [endosome membrane] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0019722 [calcium-mediated signaling] GO:0019901 [protein kinase binding] GO:0033280 [response to vitamin D] GO:0034220 [ion transmembrane transport] GO:0034765 [regulation of ion transmembrane transport] GO:0042802 [identical protein binding] GO:0051209 [release of sequestered calcium ion into cytosol] GO:0055085 [transmembrane transport] GO:0070588 [calcium ion transmembrane transport] GO:0072345 [NAADP-sensitive calcium-release channel activity] GO:0086010 [membrane depolarization during action potential] Show all	752 aa 85.2 kDa	No	>9
TPCN2-003 ENSP00000445551 ENST00000542467	E7ETX0 [Direct mapping] Two pore calcium channel protein 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005216 [ion channel activity] GO:0005245 [voltage-gated calcium channel activity] GO:0005886 [plasma membrane] GO:0006811 [ion transport] GO:0006816 [calcium ion transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0034220 [ion transmembrane transport] GO:0034765 [regulation of ion transmembrane transport] GO:0055085 [transmembrane transport] GO:0070588 [calcium ion transmembrane transport] GO:0086010 [membrane depolarization during action potential] Show all	570 aa 64.6 kDa	No	7

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.