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TPCN2

GENERAL INFORMATION

Gene name

 TPCN2

Gene description

 Two pore segment channel 2

Protein class

 Predicted membrane proteins
Transporters
Voltage-gated ion channels

Predicted localization

 Membrane

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General membranous cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
HPA027080
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PROGNOSTIC SUMMARY
Prognostic marker in ovarian cancer (unfavourable) and head and neck cancer (unfavourable).
Ovarian cancer p<0.001
Head and neck cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA027080

GENE INFORMATION

Gene name

 TPCN2 (HGNC Symbol)

Synonyms

 TPC2

Description

 Two pore segment channel 2 (HGNC Symbol)

Entrez gene summary

 This gene encodes a putative cation-selective ion channel with two repeats of a six-transmembrane-domain. The protein localizes to lysosomal membranes and enables nicotinic acid adenine dinucleotide phosphate (NAADP) -induced calcium ion release from lysosome-related stores. This ubiquitously expressed gene has elevated expression in liver and kidney. Two common nonsynonymous SNPs in this gene strongly associate with blond versus brown hair pigmentation.[provided by RefSeq, Dec 2009]

Chromosome

 11

Cytoband

 q13.3

Chromosome location (bp)

 69048897 - 69090604

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000162341 (version 83.38)

Entrez gene

 219931

UniProt

 Q8NHX9 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8NHX9

Antibodypedia

 TPCN2 antibodies

PROTEIN BROWSER
TPCN2-001
TPCN2-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TPCN2-001
ENSP00000294309
ENST00000294309
Q8NHX9 [Direct mapping]
Two pore calcium channel protein 2
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Transporters
   Transporter channels and pores
Voltage-gated ion channels
   CatSper and Two-Pore Channels
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0005216 [ion channel activity]
GO:0005245 [voltage-gated calcium channel activity]
GO:0005515 [protein binding]
GO:0005764 [lysosome]
GO:0005765 [lysosomal membrane]
GO:0005886 [plasma membrane]
GO:0006811 [ion transport]
GO:0006816 [calcium ion transport]
GO:0006874 [cellular calcium ion homeostasis]
GO:0006939 [smooth muscle contraction]
GO:0007040 [lysosome organization]
GO:0010008 [endosome membrane]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0019722 [calcium-mediated signaling]
GO:0019901 [protein kinase binding]
GO:0033280 [response to vitamin D]
GO:0034220 [ion transmembrane transport]
GO:0034765 [regulation of ion transmembrane transport]
GO:0042802 [identical protein binding]
GO:0051209 [release of sequestered calcium ion into cytosol]
GO:0055085 [transmembrane transport]
GO:0070588 [calcium ion transmembrane transport]
GO:0072345 [NAADP-sensitive calcium-release channel activity]
GO:0086010 [membrane depolarization during action potential]
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 752 aa
85.2 kDa 		No >9
TPCN2-003
ENSP00000445551
ENST00000542467
E7ETX0 [Direct mapping]
Two pore calcium channel protein 2
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
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GO:0005216 [ion channel activity]
GO:0005245 [voltage-gated calcium channel activity]
GO:0005886 [plasma membrane]
GO:0006811 [ion transport]
GO:0006816 [calcium ion transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0034220 [ion transmembrane transport]
GO:0034765 [regulation of ion transmembrane transport]
GO:0055085 [transmembrane transport]
GO:0070588 [calcium ion transmembrane transport]
GO:0086010 [membrane depolarization during action potential]
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 570 aa
64.6 kDa 		No 7

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.