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RBP7

GENERAL INFORMATION

Gene name

 RBP7

Gene description

 Retinol binding protein 7, cellular

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (EFO-21, T-47d)
HPA (normal tissue):Tissue enhanced (adipose tissue)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Nuclear expression in most tissues, highly abundant in adipocytes.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA034749
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PROGNOSTIC SUMMARY
Prognostic marker in colorectal cancer (unfavourable).
Colorectal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA034749

GENE INFORMATION

Gene name

 RBP7 (HGNC Symbol)

Synonyms

 CRBPIV

Description

 Retinol binding protein 7, cellular (HGNC Symbol)

Entrez gene summary

 Due to its chemical instability and low solubility in aqueous solution, vitamin A requires cellular retinol-binding proteins (CRBPs), such as RBP7, for stability, internalization, intercellular transfer, homeostasis, and metabolism.[supplied by OMIM, May 2004]

Chromosome

 1

Cytoband

 p36.22

Chromosome location (bp)

 9997206 - 10016020

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000162444 (version 83.38)

Entrez gene

 116362

UniProt

 Q96R05 (UniProt - Evidence at protein level)

neXtProt

 NX_Q96R05

Antibodypedia

 RBP7 antibodies

PROTEIN BROWSER
RBP7-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
RBP7-001
ENSP00000294435
ENST00000294435
Q96R05 [Direct mapping]
Retinoid-binding protein 7
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0005215 [transporter activity]
GO:0005501 [retinoid binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0006810 [transport]
GO:0008289 [lipid binding]
GO:0016918 [retinal binding]
GO:0019841 [retinol binding]
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 134 aa
15.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.