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ALPL

GENERAL INFORMATION

Gene name

 ALPL

Gene description

 Alkaline phosphatase, liver/bone/kidney

Protein class

 Cancer-related genes
Disease related genes
Enzymes
Plasma proteins
Potential drug targets
Predicted intracellular proteins
Predicted membrane proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Membrane,Secreted

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Group enriched (LHCN-M2, NTERA-2, SCLC-21H)
HPA (normal tissue):Tissue enhanced (lung)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in several tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Approved based on 3 antibodies.
HPA007105 , HPA008765 , CAB020829
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PROGNOSTIC SUMMARY
Prognostic marker in melanoma (unfavourable).
Melanoma p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA007105
HPA008765
CAB020829

GENE INFORMATION

Gene name

 ALPL (HGNC Symbol)

Synonyms

 HOPS, TNSALP

Description

 Alkaline phosphatase, liver/bone/kidney (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the alkaline phosphatase family of proteins. There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The first three are located together on chromosome 2, while the tissue non-specific form is located on chromosome 1. The product of this gene is a membrane bound glycosylated enzyme that is not expressed in any particular tissue and is, therefore, referred to as the tissue-nonspecific form of the enzyme. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature enzyme. This enzyme may play a role in bone mineralization. Mutations in this gene have been linked to hypophosphatasia, a disorder that is characterized by hypercalcemia and skeletal defects. [provided by RefSeq, Oct 2015]

Chromosome

 1

Cytoband

 p36.12

Chromosome location (bp)

 21509372 - 21578412

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000162551 (version 83.38)

Entrez gene

 249

UniProt

 P05186 (UniProt - Evidence at protein level)

neXtProt

 NX_P05186

Antibodypedia

 ALPL antibodies

PROTEIN BROWSER
ALPL-001
ALPL-002
ALPL-004
ALPL-006
ALPL-007

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ALPL-001
ENSP00000363973
ENST00000374840
P05186 [Direct mapping]
Alkaline phosphatase, tissue-nonspecific isozyme
A0A024RAG0 [Target identity:100%; Query identity:100%]
Alkaline phosphatase
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Enzymes
   ENZYME proteins
   Hydrolases
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001501 [skeletal system development]
GO:0001649 [osteoblast differentiation]
GO:0001958 [endochondral ossification]
GO:0003006 [developmental process involved in reproduction]
GO:0003824 [catalytic activity]
GO:0004035 [alkaline phosphatase activity]
GO:0005515 [protein binding]
GO:0005578 [proteinaceous extracellular matrix]
GO:0005615 [extracellular space]
GO:0005886 [plasma membrane]
GO:0008152 [metabolic process]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016311 [dephosphorylation]
GO:0016462 [pyrophosphatase activity]
GO:0016791 [phosphatase activity]
GO:0031225 [anchored component of membrane]
GO:0032496 [response to lipopolysaccharide]
GO:0033280 [response to vitamin D]
GO:0046677 [response to antibiotic]
GO:0046872 [metal ion binding]
GO:0051384 [response to glucocorticoid]
GO:0065010 [extracellular membrane-bounded organelle]
GO:0070062 [extracellular exosome]
GO:0071407 [cellular response to organic cyclic compound]
GO:0071529 [cementum mineralization]
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 524 aa
57.3 kDa 		Yes 0
ALPL-002
ENSP00000363965
ENST00000374832
P05186 [Direct mapping]
Alkaline phosphatase, tissue-nonspecific isozyme
A0A024RAG0 [Target identity:100%; Query identity:100%]
Alkaline phosphatase
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001501 [skeletal system development]
GO:0001649 [osteoblast differentiation]
GO:0003824 [catalytic activity]
GO:0004035 [alkaline phosphatase activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0008152 [metabolic process]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016462 [pyrophosphatase activity]
GO:0016791 [phosphatase activity]
GO:0031225 [anchored component of membrane]
GO:0033280 [response to vitamin D]
GO:0046872 [metal ion binding]
GO:0070062 [extracellular exosome]
Show all
 524 aa
57.3 kDa 		Yes 0
ALPL-004
ENSP00000363963
ENST00000374830
B1ANL0 [Direct mapping]
Alkaline phosphatase, tissue-nonspecific isozyme
Show all
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0008152 [metabolic process]
GO:0016311 [dephosphorylation]
GO:0016791 [phosphatase activity]
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 216 aa
23 kDa 		No 0
ALPL-006
ENSP00000437674
ENST00000539907
P05186 [Direct mapping]
Alkaline phosphatase, tissue-nonspecific isozyme
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001501 [skeletal system development]
GO:0001649 [osteoblast differentiation]
GO:0003824 [catalytic activity]
GO:0004035 [alkaline phosphatase activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0008152 [metabolic process]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016462 [pyrophosphatase activity]
GO:0016791 [phosphatase activity]
GO:0031225 [anchored component of membrane]
GO:0033280 [response to vitamin D]
GO:0046872 [metal ion binding]
GO:0070062 [extracellular exosome]
Show all
 447 aa
48.9 kDa 		No 1
ALPL-007
ENSP00000442672
ENST00000540617
P05186 [Direct mapping]
Alkaline phosphatase, tissue-nonspecific isozyme
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001501 [skeletal system development]
GO:0001649 [osteoblast differentiation]
GO:0003824 [catalytic activity]
GO:0004035 [alkaline phosphatase activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0008152 [metabolic process]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016462 [pyrophosphatase activity]
GO:0016791 [phosphatase activity]
GO:0031225 [anchored component of membrane]
GO:0033280 [response to vitamin D]
GO:0046872 [metal ion binding]
GO:0070062 [extracellular exosome]
Show all
 469 aa
51 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.