Tissue expression of ALPL - Summary - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

ALPL

TISSUE

CELL

PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	ALPL
Gene description	Alkaline phosphatase, liver/bone/kidney
Protein class	Cancer-related genes Disease related genes Enzymes Plasma proteins Potential drug targets Predicted intracellular proteins Predicted membrane proteins Predicted secreted proteins
Predicted localization	Intracellular,Membrane,Secreted
Number of transcripts	5
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enhanced (lung)
GTEx:	Mixed
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic expression in several tissues.

DATA RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data.
Reliability score	Approved based on 3 antibodies. HPA007105 , HPA008765 , CAB020829
	SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (lung)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Mixed
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	ALPL (HGNC Symbol)
Synonyms	HOPS, TNSALP
Description	Alkaline phosphatase, liver/bone/kidney (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the alkaline phosphatase family of proteins. There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The first three are located together on chromosome 2, while the tissue non-specific form is located on chromosome 1. The product of this gene is a membrane bound glycosylated enzyme that is not expressed in any particular tissue and is, therefore, referred to as the tissue-nonspecific form of the enzyme. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature enzyme. This enzyme may play a role in bone mineralization. Mutations in this gene have been linked to hypophosphatasia, a disorder that is characterized by hypercalcemia and skeletal defects. [provided by RefSeq, Oct 2015]
Chromosome	1
Cytoband	p36.12
Chromosome location (bp)	21509372 - 21578412
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000162551 (version 83.38)
Entrez gene	249
UniProt	P05186 (UniProt - Evidence at protein level)
neXtProt	NX_P05186
Antibodypedia	ALPL antibodies

PROTEIN BROWSER

ALPL-001	ALPL-002	ALPL-004	ALPL-006	ALPL-007

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ALPL-001 ENSP00000363973 ENST00000374840	P05186 [Direct mapping] Alkaline phosphatase, tissue-nonspecific isozyme A0A024RAG0 [Target identity:100%; Query identity:100%] Alkaline phosphatase Show all	Enzymes ENZYME proteins Hydrolases MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001501 [skeletal system development] GO:0001649 [osteoblast differentiation] GO:0001958 [endochondral ossification] GO:0003006 [developmental process involved in reproduction] GO:0003824 [catalytic activity] GO:0004035 [alkaline phosphatase activity] GO:0005515 [protein binding] GO:0005578 [proteinaceous extracellular matrix] GO:0005615 [extracellular space] GO:0005886 [plasma membrane] GO:0008152 [metabolic process] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016311 [dephosphorylation] GO:0016462 [pyrophosphatase activity] GO:0016791 [phosphatase activity] GO:0031225 [anchored component of membrane] GO:0032496 [response to lipopolysaccharide] GO:0033280 [response to vitamin D] GO:0046677 [response to antibiotic] GO:0046872 [metal ion binding] GO:0051384 [response to glucocorticoid] GO:0065010 [extracellular membrane-bounded organelle] GO:0070062 [extracellular exosome] GO:0071407 [cellular response to organic cyclic compound] GO:0071529 [cementum mineralization] Show all	524 aa 57.3 kDa	Yes	0
ALPL-002 ENSP00000363965 ENST00000374832	P05186 [Direct mapping] Alkaline phosphatase, tissue-nonspecific isozyme A0A024RAG0 [Target identity:100%; Query identity:100%] Alkaline phosphatase Show all	Enzymes ENZYME proteins Hydrolases MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0001501 [skeletal system development] GO:0001649 [osteoblast differentiation] GO:0003824 [catalytic activity] GO:0004035 [alkaline phosphatase activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0008152 [metabolic process] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016462 [pyrophosphatase activity] GO:0016791 [phosphatase activity] GO:0031225 [anchored component of membrane] GO:0033280 [response to vitamin D] GO:0046872 [metal ion binding] GO:0070062 [extracellular exosome] Show all	524 aa 57.3 kDa	Yes	0
ALPL-004 ENSP00000363963 ENST00000374830	B1ANL0 [Direct mapping] Alkaline phosphatase, tissue-nonspecific isozyme Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0008152 [metabolic process] GO:0016311 [dephosphorylation] GO:0016791 [phosphatase activity] Show all	216 aa 23 kDa	No	0
ALPL-006 ENSP00000437674 ENST00000539907	P05186 [Direct mapping] Alkaline phosphatase, tissue-nonspecific isozyme Show all	Enzymes ENZYME proteins Hydrolases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Cancer-related genes Candidate cancer biomarkers Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001501 [skeletal system development] GO:0001649 [osteoblast differentiation] GO:0003824 [catalytic activity] GO:0004035 [alkaline phosphatase activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0008152 [metabolic process] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016462 [pyrophosphatase activity] GO:0016791 [phosphatase activity] GO:0031225 [anchored component of membrane] GO:0033280 [response to vitamin D] GO:0046872 [metal ion binding] GO:0070062 [extracellular exosome] Show all	447 aa 48.9 kDa	No	1
ALPL-007 ENSP00000442672 ENST00000540617	P05186 [Direct mapping] Alkaline phosphatase, tissue-nonspecific isozyme Show all	Enzymes ENZYME proteins Hydrolases MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001501 [skeletal system development] GO:0001649 [osteoblast differentiation] GO:0003824 [catalytic activity] GO:0004035 [alkaline phosphatase activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0008152 [metabolic process] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016462 [pyrophosphatase activity] GO:0016791 [phosphatase activity] GO:0031225 [anchored component of membrane] GO:0033280 [response to vitamin D] GO:0046872 [metal ion binding] GO:0070062 [extracellular exosome] Show all	469 aa 51 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.