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Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

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Searches

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Expression

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Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

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Score

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Antibodies

Column

 
 
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ALPL
  • TISSUE

  • CELL

  • PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

ALPL

Gene description

Alkaline phosphatase, liver/bone/kidney

Protein class

Cancer-related genes
Disease related genes
Enzymes
Plasma proteins
Potential drug targets
Predicted intracellular proteins
Predicted membrane proteins
Predicted secreted proteins

Predicted localization

Intracellular,Membrane,Secreted

Number of transcripts

5
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Tissue enhanced (lung)
GTEx:Mixed
FANTOM5:Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic expression in several tissues.

DATA RELIABILITY

Data reliability
description

Antibody staining mainly not consistent with RNA expression data.

Reliability score

Approved based on 3 antibodies.
HPA007105 , HPA008765 , CAB020829
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Adrenal gland

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (lung)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

ALPL (HGNC Symbol)

Synonyms

HOPS, TNSALP

Description

Alkaline phosphatase, liver/bone/kidney (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the alkaline phosphatase family of proteins. There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The first three are located together on chromosome 2, while the tissue non-specific form is located on chromosome 1. The product of this gene is a membrane bound glycosylated enzyme that is not expressed in any particular tissue and is, therefore, referred to as the tissue-nonspecific form of the enzyme. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature enzyme. This enzyme may play a role in bone mineralization. Mutations in this gene have been linked to hypophosphatasia, a disorder that is characterized by hypercalcemia and skeletal defects. [provided by RefSeq, Oct 2015]

Chromosome

1

Cytoband

p36.12

Chromosome location (bp)

21509372 - 21578412

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000162551 (version 83.38)

Entrez gene

249

UniProt

P05186 (UniProt - Evidence at protein level)

neXtProt

NX_P05186

Antibodypedia

ALPL antibodies

PROTEIN BROWSER

ALPL-001
ALPL-002
ALPL-004
ALPL-006
ALPL-007

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ALPL-001
ENSP00000363973
ENST00000374840
P05186 [Direct mapping]
Alkaline phosphatase, tissue-nonspecific isozyme
A0A024RAG0 [Target identity:100%; Query identity:100%]
Alkaline phosphatase
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001501 [skeletal system development]
GO:0001649 [osteoblast differentiation]
GO:0001958 [endochondral ossification]
GO:0003006 [developmental process involved in reproduction]
GO:0003824 [catalytic activity]
GO:0004035 [alkaline phosphatase activity]
GO:0005515 [protein binding]
GO:0005578 [proteinaceous extracellular matrix]
GO:0005615 [extracellular space]
GO:0005886 [plasma membrane]
GO:0008152 [metabolic process]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016311 [dephosphorylation]
GO:0016462 [pyrophosphatase activity]
GO:0016791 [phosphatase activity]
GO:0031225 [anchored component of membrane]
GO:0032496 [response to lipopolysaccharide]
GO:0033280 [response to vitamin D]
GO:0046677 [response to antibiotic]
GO:0046872 [metal ion binding]
GO:0051384 [response to glucocorticoid]
GO:0065010 [extracellular membrane-bounded organelle]
GO:0070062 [extracellular exosome]
GO:0071407 [cellular response to organic cyclic compound]
GO:0071529 [cementum mineralization]
Show all
524 aa
57.3 kDa
Yes 0
ALPL-002
ENSP00000363965
ENST00000374832
P05186 [Direct mapping]
Alkaline phosphatase, tissue-nonspecific isozyme
A0A024RAG0 [Target identity:100%; Query identity:100%]
Alkaline phosphatase
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001501 [skeletal system development]
GO:0001649 [osteoblast differentiation]
GO:0003824 [catalytic activity]
GO:0004035 [alkaline phosphatase activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0008152 [metabolic process]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016462 [pyrophosphatase activity]
GO:0016791 [phosphatase activity]
GO:0031225 [anchored component of membrane]
GO:0033280 [response to vitamin D]
GO:0046872 [metal ion binding]
GO:0070062 [extracellular exosome]
Show all
524 aa
57.3 kDa
Yes 0
ALPL-004
ENSP00000363963
ENST00000374830
B1ANL0 [Direct mapping]
Alkaline phosphatase, tissue-nonspecific isozyme
Show all
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0008152 [metabolic process]
GO:0016311 [dephosphorylation]
GO:0016791 [phosphatase activity]
Show all
216 aa
23 kDa
No 0
ALPL-006
ENSP00000437674
ENST00000539907
P05186 [Direct mapping]
Alkaline phosphatase, tissue-nonspecific isozyme
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001501 [skeletal system development]
GO:0001649 [osteoblast differentiation]
GO:0003824 [catalytic activity]
GO:0004035 [alkaline phosphatase activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0008152 [metabolic process]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016462 [pyrophosphatase activity]
GO:0016791 [phosphatase activity]
GO:0031225 [anchored component of membrane]
GO:0033280 [response to vitamin D]
GO:0046872 [metal ion binding]
GO:0070062 [extracellular exosome]
Show all
447 aa
48.9 kDa
No 1
ALPL-007
ENSP00000442672
ENST00000540617
P05186 [Direct mapping]
Alkaline phosphatase, tissue-nonspecific isozyme
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001501 [skeletal system development]
GO:0001649 [osteoblast differentiation]
GO:0003824 [catalytic activity]
GO:0004035 [alkaline phosphatase activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0008152 [metabolic process]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016462 [pyrophosphatase activity]
GO:0016791 [phosphatase activity]
GO:0031225 [anchored component of membrane]
GO:0033280 [response to vitamin D]
GO:0046872 [metal ion binding]
GO:0070062 [extracellular exosome]
Show all
469 aa
51 kDa
No 0

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