Cell atlas - SNX7 - The Human Protein Atlas

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SNX7

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Nucleoli fibrillar center

Human cell
	Cytosol
	Nucleoli

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GENERAL INFORMATION
Gene name	SNX7
Gene description	Sorting nexin 7
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the cytosol & nucleoli (fibrillar center).
RNA cell category	Mixed
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoli fibrillar center (approved), Cytosol (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA054338
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Mixed Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the cytosol & nucleoli (fibrillar center).

Main location

Nucleoli fibrillar center (approved), Cytosol (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA054338	A-431	Nucleoli fibrillar center
	HPA054338	A-431	Cytosol
	HPA054338	U-2 OS	Nucleoli fibrillar center
	HPA054338	U-2 OS	Cytosol
	HPA054338	U-251 MG	Nucleoli fibrillar center
	HPA054338	U-251 MG	Cytosol

GENE INFORMATION
Gene name	SNX7
Synonyms
Description	Sorting nexin 7 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled coil region like some family members, and its exact function is unknown. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 11. [provided by RefSeq, Jun 2010]
Chromosome	1
Cytoband	p21.3
Chromosome location (bp)	98661701 - 98760500
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000162627 (version 83.38)
Entrez gene	51375
UniProt	Q9UNH6 (UniProt - Evidence at protein level)
neXtProt	NX_Q9UNH6
Antibodypedia	SNX7 antibodies

PROTEIN BROWSER

SNX7-001	SNX7-004	SNX7-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SNX7-001 ENSP00000304429 ENST00000306121	Q9UNH6 [Direct mapping] Sorting nexin-7 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005768 [endosome] GO:0006897 [endocytosis] GO:0015031 [protein transport] GO:0016050 [vesicle organization] GO:0019898 [extrinsic component of membrane] GO:0030659 [cytoplasmic vesicle membrane] GO:0035091 [phosphatidylinositol binding] Show all	451 aa 51.6 kDa	No	0
SNX7-004 ENSP00000388266 ENST00000454199	B7ZC83 [Direct mapping] Sorting nexin-7 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005768 [endosome] GO:0006897 [endocytosis] GO:0016050 [vesicle organization] GO:0019898 [extrinsic component of membrane] GO:0035091 [phosphatidylinositol binding] Show all	108 aa 12.7 kDa	No	0
SNX7-005 ENSP00000434731 ENST00000529992	E9PNL2 [Direct mapping] Sorting nexin-7 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005768 [endosome] GO:0006897 [endocytosis] GO:0016050 [vesicle organization] GO:0019898 [extrinsic component of membrane] GO:0035091 [phosphatidylinositol binding] Show all	396 aa 45 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.