Expression of SNX7 in cancer - Summary - The Human Protein Atlas

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SNX7

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	SNX7
Gene description	Sorting nexin 7
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Mixed
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Ubiquitous cytoplasmic expression with a granular pattern.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA037419
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable) and colorectal cancer (favourable).
Liver cancer p<0.001 Colorectal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA037419

GENE INFORMATION
Gene name	SNX7
Synonyms
Description	Sorting nexin 7 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled coil region like some family members, and its exact function is unknown. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 11. [provided by RefSeq, Jun 2010]
Chromosome	1
Cytoband	p21.3
Chromosome location (bp)	98661701 - 98760500
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000162627 (version 83.38)
Entrez gene	51375
UniProt	Q9UNH6 (UniProt - Evidence at protein level)
neXtProt	NX_Q9UNH6
Antibodypedia	SNX7 antibodies

PROTEIN BROWSER

SNX7-001	SNX7-004	SNX7-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SNX7-001 ENSP00000304429 ENST00000306121	Q9UNH6 [Direct mapping] Sorting nexin-7 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005768 [endosome] GO:0006897 [endocytosis] GO:0015031 [protein transport] GO:0016050 [vesicle organization] GO:0019898 [extrinsic component of membrane] GO:0030659 [cytoplasmic vesicle membrane] GO:0035091 [phosphatidylinositol binding] Show all	451 aa 51.6 kDa	No	0
SNX7-004 ENSP00000388266 ENST00000454199	B7ZC83 [Direct mapping] Sorting nexin-7 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005768 [endosome] GO:0006897 [endocytosis] GO:0016050 [vesicle organization] GO:0019898 [extrinsic component of membrane] GO:0035091 [phosphatidylinositol binding] Show all	108 aa 12.7 kDa	No	0
SNX7-005 ENSP00000434731 ENST00000529992	E9PNL2 [Direct mapping] Sorting nexin-7 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005768 [endosome] GO:0006897 [endocytosis] GO:0016050 [vesicle organization] GO:0019898 [extrinsic component of membrane] GO:0035091 [phosphatidylinositol binding] Show all	396 aa 45 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.