Cell atlas - GBP4 - The Human Protein Atlas

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GBP4

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Plasma membrane

Human cell
	Plasma Membrane

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GENERAL INFORMATION
Gene name	GBP4
Gene description	Guanylate binding protein 4
Protein class	Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the plasma membrane.
RNA cell category	Cell line enhanced (RT4, U-266/70, HEL)
Protein evidence	Evidence at protein level
Main location	Localized to the Plasma membrane (uncertain)

DATA RELIABILITY
Reliability score	Uncertain based on 1 antibody. HPA062039
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (RT4, U-266/70, HEL) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the plasma membrane.

Main location

Plasma membrane (uncertain)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA062039	BJ	Plasma membrane
	HPA062039	U-2 OS	Plasma membrane

GENE INFORMATION
Gene name	GBP4 (HGNC Symbol)
Synonyms	Mpa2
Description	Guanylate binding protein 4 (HGNC Symbol)
Entrez gene summary	Guanylate-binding proteins, such as GBP4, are induced by interferon and hydrolyze GTP to both GDP and GMP (Vestal, 2005 [PubMed 16108726]).[supplied by OMIM, Dec 2008]
Chromosome	1
Cytoband	p22.2
Chromosome location (bp)	89181148 - 89198932
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000162654 (version 83.38)
Entrez gene	115361
UniProt	Q96PP9 (UniProt - Evidence at transcript level)
neXtProt	NX_Q96PP9
Antibodypedia	GBP4 antibodies

PROTEIN BROWSER

GBP4-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GBP4-001 ENSP00000359490 ENST00000355754	Q96PP9 [Direct mapping] Guanylate-binding protein 4 Show all	MEMSAT3 predicted membrane proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0003924 [GTPase activity] GO:0005525 [GTP binding] GO:0005634 [nucleus] GO:0008152 [metabolic process] GO:0048471 [perinuclear region of cytoplasm] Show all	640 aa 73.2 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.