Expression of SLAMF6 in cancer - Summary

GENERAL INFORMATION
Gene name	SLAMF6
Gene description	SLAM family member 6
Protein class	CD markers Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Cell line enhanced (Daudi, U-698)
HPA (normal tissue):	Tissue enhanced (lymph node, spleen, tonsil)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in lymphoid cells in lymhoid organs and gastrointestinal tract.

ANTIBODY IHC RELIABILITY
Data reliability description	Pending external verification.
Reliability score	Uncertain based on 2 antibodies. HPA051363 , HPA051903
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable), head and neck cancer (favourable), melanoma (favourable), cervical cancer (favourable), breast cancer (favourable) and endometrial cancer (favourable).
Renal cancer p<0.001 Head and neck cancer p<0.001 Melanoma p<0.001 Cervical cancer p<0.001 Breast cancer p<0.001 Endometrial cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

STAINING SUMMARY

HPA051363	HPA051903

GENE INFORMATION
Gene name	SLAMF6 (HGNC Symbol)
Synonyms	CD352, KALI, KALIb, Ly108, NTB-A, NTBA, SF2000
Description	SLAM family member 6 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a type I transmembrane protein, belonging to the CD2 subfamily of the immunoglobulin superfamily. This encoded protein is expressed on Natural killer (NK), T, and B lymphocytes. It undergoes tyrosine phosphorylation and associates with the Src homology 2 domain-containing protein (SH2D1A) as well as with SH2 domain-containing phosphatases (SHPs). It functions as a coreceptor in the process of NK cell activation. It can also mediate inhibitory signals in NK cells from X-linked lymphoproliferative patients. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, May 2010]
Chromosome	1
Cytoband
Chromosome location (bp)	160485030 - 160523262
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000162739 (version 83.38)
Entrez gene	114836
UniProt	Q96DU3 (UniProt - Evidence at protein level)
neXtProt	NX_Q96DU3
Antibodypedia	SLAMF6 antibodies

PROTEIN BROWSER

SLAMF6-001	SLAMF6-002	SLAMF6-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SLAMF6-001 ENSP00000357036 ENST00000368057	Q96DU3 [Direct mapping] SLAM family member 6 Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004872 [receptor activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0016021 [integral component of membrane] GO:0050776 [regulation of immune response] GO:0070062 [extracellular exosome] Show all	332 aa 37.3 kDa	Yes	1
SLAMF6-002 ENSP00000357038 ENST00000368059	Q96DU3 [Direct mapping] SLAM family member 6 Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004872 [receptor activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0016021 [integral component of membrane] GO:0050776 [regulation of immune response] GO:0070062 [extracellular exosome] Show all	331 aa 37.3 kDa	Yes	1
SLAMF6-003 ENSP00000357034 ENST00000368055	Q96DU3 [Direct mapping] SLAM family member 6 Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004872 [receptor activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0016021 [integral component of membrane] GO:0050776 [regulation of immune response] GO:0070062 [extracellular exosome] Show all	221 aa 25 kDa	Yes	1