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SLAMF6

GENERAL INFORMATION

Gene name

 SLAMF6

Gene description

 SLAM family member 6

Protein class

 CD markers
Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (lymph node, spleen, tonsil)
GTEx:Group enriched (small intestine, spleen)
FANTOM5:Tissue enhanced (appendix, lymph node, spleen, tonsil)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in lymphoid cells in lymhoid organs and gastrointestinal tract.

DATA RELIABILITY

Data reliability
description

 Pending external verification.

Reliability score

 Uncertain based on 2 antibodies.
HPA051363 , HPA051903
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Tonsil

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (lymph node, spleen, tonsil)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (small intestine, spleen)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (appendix, lymph node, spleen, tonsil)

GENE INFORMATION

Gene name

 SLAMF6 (HGNC Symbol)

Synonyms

 CD352, KALI, KALIb, Ly108, NTB-A, NTBA, SF2000

Description

 SLAM family member 6 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a type I transmembrane protein, belonging to the CD2 subfamily of the immunoglobulin superfamily. This encoded protein is expressed on Natural killer (NK), T, and B lymphocytes. It undergoes tyrosine phosphorylation and associates with the Src homology 2 domain-containing protein (SH2D1A) as well as with SH2 domain-containing phosphatases (SHPs). It functions as a coreceptor in the process of NK cell activation. It can also mediate inhibitory signals in NK cells from X-linked lymphoproliferative patients. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, May 2010]

Chromosome

 1

Cytoband

Chromosome location (bp)

 160485030 - 160523262

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000162739 (version 83.38)

Entrez gene

 114836

UniProt

 Q96DU3 (UniProt - Evidence at protein level)

neXtProt

 NX_Q96DU3

Antibodypedia

 SLAMF6 antibodies

PROTEIN BROWSER
SLAMF6-001
SLAMF6-002
SLAMF6-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SLAMF6-001
ENSP00000357036
ENST00000368057
Q96DU3 [Direct mapping]
SLAM family member 6
Show all
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004872 [receptor activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0016021 [integral component of membrane]
GO:0050776 [regulation of immune response]
GO:0070062 [extracellular exosome]
Show all
 332 aa
37.3 kDa 		Yes 1
SLAMF6-002
ENSP00000357038
ENST00000368059
Q96DU3 [Direct mapping]
SLAM family member 6
Show all
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004872 [receptor activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0016021 [integral component of membrane]
GO:0050776 [regulation of immune response]
GO:0070062 [extracellular exosome]
Show all
 331 aa
37.3 kDa 		Yes 1
SLAMF6-003
ENSP00000357034
ENST00000368055
Q96DU3 [Direct mapping]
SLAM family member 6
Show all
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004872 [receptor activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0016021 [integral component of membrane]
GO:0050776 [regulation of immune response]
GO:0070062 [extracellular exosome]
Show all
 221 aa
25 kDa 		Yes 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.