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A majority of cancer tissues displayed weak to moderate cytoplasmic with additional membranous positivity in a few cases. Several cases of testicular, pancreatic cancers along with a few cases of breast cancers were strongly stained. Some cases of skin and cervical cancers were negative.
GENE INFORMATION
Gene name
FLVCR1 (HGNC Symbol)
Synonyms
AXPC1, FLVCR, MFSD7B, PCA
Description
Feline leukemia virus subgroup C cellular receptor 1 (HGNC Symbol)
Entrez gene summary
This gene encodes a member of the major facilitator superfamily of transporter proteins. The encoded protein is a heme transporter that may play a critical role in erythropoiesis by protecting developing erythroid cells from heme toxicity. This gene may play a role in posterior column ataxia with retinitis pigmentosa and the hematological disorder Diamond-Blackfan syndrome. [provided by RefSeq, Jan 2011]