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FLVCR1

GENERAL INFORMATION

Gene name

 FLVCR1

Gene description

 Feline leukemia virus subgroup C cellular receptor 1

Protein class

 Disease related genes
Potential drug targets
Predicted membrane proteins
Transporters

Predicted localization

 Membrane

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (small intestine)
GTEx:Mixed
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in most tissues. Membranous expression especially in the gastrointestinal tract.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded.

Reliability score

 Approved based on 1 antibody.
HPA046646
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Small intestine

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (small intestine)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 FLVCR1 (HGNC Symbol)

Synonyms

 AXPC1, FLVCR, MFSD7B, PCA

Description

 Feline leukemia virus subgroup C cellular receptor 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the major facilitator superfamily of transporter proteins. The encoded protein is a heme transporter that may play a critical role in erythropoiesis by protecting developing erythroid cells from heme toxicity. This gene may play a role in posterior column ataxia with retinitis pigmentosa and the hematological disorder Diamond-Blackfan syndrome. [provided by RefSeq, Jan 2011]

Chromosome

 1

Cytoband

 q32.3

Chromosome location (bp)

 212858255 - 212899363

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000162769 (version 83.38)

Entrez gene

 28982

UniProt

 Q9Y5Y0 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9Y5Y0

Antibodypedia

 FLVCR1 antibodies

PROTEIN BROWSER
FLVCR1-001
FLVCR1-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
FLVCR1-001
ENSP00000355938
ENST00000366971
Q9Y5Y0 [Direct mapping]
Feline leukemia virus subgroup C receptor-related protein 1
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Transporters
   Electrochemical Potential-driven transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001568 [blood vessel development]
GO:0001701 [in utero embryonic development]
GO:0005215 [transporter activity]
GO:0005515 [protein binding]
GO:0005739 [mitochondrion]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006810 [transport]
GO:0006839 [mitochondrial transport]
GO:0006879 [cellular iron ion homeostasis]
GO:0007275 [multicellular organismal development]
GO:0015232 [heme transporter activity]
GO:0015886 [heme transport]
GO:0016021 [integral component of membrane]
GO:0030218 [erythrocyte differentiation]
GO:0031966 [mitochondrial membrane]
GO:0035108 [limb morphogenesis]
GO:0035264 [multicellular organism growth]
GO:0042733 [embryonic digit morphogenesis]
GO:0043249 [erythrocyte maturation]
GO:0046620 [regulation of organ growth]
GO:0048536 [spleen development]
GO:0048704 [embryonic skeletal system morphogenesis]
GO:0055085 [transmembrane transport]
GO:0060323 [head morphogenesis]
GO:0097037 [heme export]
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 555 aa
59.9 kDa 		No >9
FLVCR1-004
ENSP00000414680
ENST00000419102
H7C3Z2 [Direct mapping]
Feline leukemia virus subgroup C receptor-related protein 1
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0016021 [integral component of membrane]
GO:0055085 [transmembrane transport]
Show all
 354 aa
38.1 kDa 		No 7

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.