Expression of IER5 in cancer - Summary - The Human Protein Atlas

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IER5

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	IER5
Gene description	Immediate early response 5
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General cytoplasmic expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA029894
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PROGNOSTIC SUMMARY
Prognostic marker in endometrial cancer (favourable), lung cancer (unfavourable) and renal cancer (unfavourable).
Endometrial cancer p<0.001 Lung cancer p<0.001 Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA029894

GENE INFORMATION
Gene name	IER5
Synonyms
Description	Immediate early response 5 (HGNC Symbol)
Entrez gene summary	This gene encodes a protein that is similar to other immediate early response proteins. In the mouse, a similar gene may play an important role in mediating the cellular response to mitogenic signals. Studies in rats found the expression of a similar gene to be increased after waking and sleep deprivation. [provided by RefSeq, Jul 2008]
Chromosome	1
Cytoband	q25.3
Chromosome location (bp)	181088712 - 181092899
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000162783 (version 83.38)
Entrez gene	51278
UniProt	Q5VY09 (UniProt - Evidence at transcript level)
neXtProt	NX_Q5VY09
Antibodypedia	IER5 antibodies

PROTEIN BROWSER

IER5-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
IER5-001 ENSP00000356549 ENST00000367577	Q5VY09 [Direct mapping] Immediate early response gene 5 protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		327 aa 33.7 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.