Expression of BPNT1 in cancer - Summary

GENERAL INFORMATION
Gene name	BPNT1
Gene description	3'(2'), 5'-bisphosphate nucleotidase 1
Protein class	Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	9
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in most tissues. Some tissues display nuclear expression as well.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA048461
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

STAINING SUMMARY

HPA048461

GENE INFORMATION
Gene name	BPNT1
Synonyms
Description	3'(2'), 5'-bisphosphate nucleotidase 1 (HGNC Symbol)
Entrez gene summary	BPNT1, also called bisphosphate 3-prime-nucleotidase, or BPntase, is a member of a magnesium-dependent phosphomonoesterase family. Lithium, a major drug used to treat manic depression, acts as an uncompetitive inhibitor of BPntase. The predicted human protein is 92% identical to mouse BPntase. BPntase's physiologic role in nucleotide metabolism may be regulated by inositol signaling pathways. The inhibition of human BPntase may account for lithium-induced nephrotoxicity. [provided by RefSeq, Jul 2008]
Chromosome	1
Cytoband	q41
Chromosome location (bp)	220057482 - 220090462
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000162813 (version 83.38)
Entrez gene	10380
UniProt	O95861 (UniProt - Evidence at protein level)
neXtProt	NX_O95861
Antibodypedia	BPNT1 antibodies

PROTEIN BROWSER

BPNT1-001	BPNT1-005	BPNT1-006	BPNT1-008	BPNT1-009	BPNT1-010	BPNT1-201	BPNT1-202	BPNT1-203

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
BPNT1-001 ENSP00000446828 ENST00000469520	O95861 [Direct mapping] 3'(2'),5'-bisphosphate nucleotidase 1 V9HWF9 [Target identity:100%; Query identity:100%] Epididymis luminal protein 20 Show all	Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000287 [magnesium ion binding] GO:0004441 [inositol-1,4-bisphosphate 1-phosphatase activity] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006139 [nucleobase-containing compound metabolic process] GO:0006805 [xenobiotic metabolic process] GO:0007399 [nervous system development] GO:0008441 [3'(2'),5'-bisphosphate nucleotidase activity] GO:0016311 [dephosphorylation] GO:0044281 [small molecule metabolic process] GO:0046854 [phosphatidylinositol phosphorylation] GO:0050427 [3'-phosphoadenosine 5'-phosphosulfate metabolic process] GO:0070062 [extracellular exosome] Show all	308 aa 33.4 kDa	No	0
BPNT1-005 ENSP00000446953 ENST00000463953	F8W1J0 [Direct mapping] 3'(2'),5'-bisphosphate nucleotidase 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0046854 [phosphatidylinositol phosphorylation] Show all	170 aa 18.3 kDa	No	0
BPNT1-006 ENSP00000449883 ENST00000498237	F8VVW8 [Direct mapping] 3'(2'),5'-bisphosphate nucleotidase 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0046854 [phosphatidylinositol phosphorylation] Show all	130 aa 14.4 kDa	No	0
BPNT1-008 ENSP00000346862 ENST00000354807	A6NF51 [Direct mapping] 3'(2'),5'-bisphosphate nucleotidase 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0046854 [phosphatidylinositol phosphorylation] Show all	291 aa 31.7 kDa	No	0
BPNT1-009 ENSP00000448740 ENST00000480959	F8VRY7 [Direct mapping] 3'(2'),5'-bisphosphate nucleotidase 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0046854 [phosphatidylinositol phosphorylation] Show all	116 aa 12.9 kDa	No	0
BPNT1-010 ENSP00000446850 ENST00000498791	F8VZG4 [Direct mapping] 3'(2'),5'-bisphosphate nucleotidase 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0046854 [phosphatidylinositol phosphorylation] Show all	136 aa 14.7 kDa	No	0
BPNT1-201 ENSP00000318852 ENST00000322067	O95861 [Direct mapping] 3'(2'),5'-bisphosphate nucleotidase 1 V9HWF9 [Target identity:100%; Query identity:100%] Epididymis luminal protein 20 Show all	Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000287 [magnesium ion binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006139 [nucleobase-containing compound metabolic process] GO:0006805 [xenobiotic metabolic process] GO:0007399 [nervous system development] GO:0008441 [3'(2'),5'-bisphosphate nucleotidase activity] GO:0016311 [dephosphorylation] GO:0044281 [small molecule metabolic process] GO:0046854 [phosphatidylinositol phosphorylation] GO:0050427 [3'-phosphoadenosine 5'-phosphosulfate metabolic process] GO:0070062 [extracellular exosome] Show all	308 aa 33.4 kDa	No	0
BPNT1-202 ENSP00000410348 ENST00000414869	O95861 [Direct mapping] 3'(2'),5'-bisphosphate nucleotidase 1 Show all	Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000287 [magnesium ion binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006139 [nucleobase-containing compound metabolic process] GO:0006805 [xenobiotic metabolic process] GO:0007399 [nervous system development] GO:0008441 [3'(2'),5'-bisphosphate nucleotidase activity] GO:0016311 [dephosphorylation] GO:0044281 [small molecule metabolic process] GO:0046854 [phosphatidylinositol phosphorylation] GO:0050427 [3'-phosphoadenosine 5'-phosphosulfate metabolic process] GO:0070062 [extracellular exosome] Show all	272 aa 29.2 kDa	No	0
BPNT1-203 ENSP00000444398 ENST00000544404	O95861 [Direct mapping] 3'(2'),5'-bisphosphate nucleotidase 1 Show all	Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000287 [magnesium ion binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006139 [nucleobase-containing compound metabolic process] GO:0006805 [xenobiotic metabolic process] GO:0007399 [nervous system development] GO:0008441 [3'(2'),5'-bisphosphate nucleotidase activity] GO:0016311 [dephosphorylation] GO:0044281 [small molecule metabolic process] GO:0046854 [phosphatidylinositol phosphorylation] GO:0050427 [3'-phosphoadenosine 5'-phosphosulfate metabolic process] GO:0070062 [extracellular exosome] Show all	253 aa 27.5 kDa	No	0