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BPNT1

GENERAL INFORMATION

Gene name

 BPNT1

Gene description

 3'(2'), 5'-bisphosphate nucleotidase 1

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 9
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in most tissues. Some tissues display nuclear expression as well.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 1 antibody.
HPA048461
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Nasopharynx
N/A
N/A
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Small intestine

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 BPNT1

Synonyms

Description

 3'(2'), 5'-bisphosphate nucleotidase 1 (HGNC Symbol)

Entrez gene summary

 BPNT1, also called bisphosphate 3-prime-nucleotidase, or BPntase, is a member of a magnesium-dependent phosphomonoesterase family. Lithium, a major drug used to treat manic depression, acts as an uncompetitive inhibitor of BPntase. The predicted human protein is 92% identical to mouse BPntase. BPntase's physiologic role in nucleotide metabolism may be regulated by inositol signaling pathways. The inhibition of human BPntase may account for lithium-induced nephrotoxicity. [provided by RefSeq, Jul 2008]

Chromosome

 1

Cytoband

 q41

Chromosome location (bp)

 220057482 - 220090462

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000162813 (version 83.38)

Entrez gene

 10380

UniProt

 O95861 (UniProt - Evidence at protein level)

neXtProt

 NX_O95861

Antibodypedia

 BPNT1 antibodies

PROTEIN BROWSER
BPNT1-001
BPNT1-005
BPNT1-006
BPNT1-008
BPNT1-009
BPNT1-010
BPNT1-201
BPNT1-202
BPNT1-203

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
BPNT1-001
ENSP00000446828
ENST00000469520
O95861 [Direct mapping]
3'(2'),5'-bisphosphate nucleotidase 1
V9HWF9 [Target identity:100%; Query identity:100%]
Epididymis luminal protein 20
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Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000287 [magnesium ion binding]
GO:0004441 [inositol-1,4-bisphosphate 1-phosphatase activity]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006139 [nucleobase-containing compound metabolic process]
GO:0006805 [xenobiotic metabolic process]
GO:0007399 [nervous system development]
GO:0008441 [3'(2'),5'-bisphosphate nucleotidase activity]
GO:0016311 [dephosphorylation]
GO:0044281 [small molecule metabolic process]
GO:0046854 [phosphatidylinositol phosphorylation]
GO:0050427 [3'-phosphoadenosine 5'-phosphosulfate metabolic process]
GO:0070062 [extracellular exosome]
Show all
 308 aa
33.4 kDa 		No 0
BPNT1-005
ENSP00000446953
ENST00000463953
F8W1J0 [Direct mapping]
3'(2'),5'-bisphosphate nucleotidase 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0046854 [phosphatidylinositol phosphorylation]
Show all
 170 aa
18.3 kDa 		No 0
BPNT1-006
ENSP00000449883
ENST00000498237
F8VVW8 [Direct mapping]
3'(2'),5'-bisphosphate nucleotidase 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0046854 [phosphatidylinositol phosphorylation]
Show all
 130 aa
14.4 kDa 		No 0
BPNT1-008
ENSP00000346862
ENST00000354807
A6NF51 [Direct mapping]
3'(2'),5'-bisphosphate nucleotidase 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0046854 [phosphatidylinositol phosphorylation]
Show all
 291 aa
31.7 kDa 		No 0
BPNT1-009
ENSP00000448740
ENST00000480959
F8VRY7 [Direct mapping]
3'(2'),5'-bisphosphate nucleotidase 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0046854 [phosphatidylinositol phosphorylation]
Show all
 116 aa
12.9 kDa 		No 0
BPNT1-010
ENSP00000446850
ENST00000498791
F8VZG4 [Direct mapping]
3'(2'),5'-bisphosphate nucleotidase 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0046854 [phosphatidylinositol phosphorylation]
Show all
 136 aa
14.7 kDa 		No 0
BPNT1-201
ENSP00000318852
ENST00000322067
O95861 [Direct mapping]
3'(2'),5'-bisphosphate nucleotidase 1
V9HWF9 [Target identity:100%; Query identity:100%]
Epididymis luminal protein 20
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000287 [magnesium ion binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006139 [nucleobase-containing compound metabolic process]
GO:0006805 [xenobiotic metabolic process]
GO:0007399 [nervous system development]
GO:0008441 [3'(2'),5'-bisphosphate nucleotidase activity]
GO:0016311 [dephosphorylation]
GO:0044281 [small molecule metabolic process]
GO:0046854 [phosphatidylinositol phosphorylation]
GO:0050427 [3'-phosphoadenosine 5'-phosphosulfate metabolic process]
GO:0070062 [extracellular exosome]
Show all
 308 aa
33.4 kDa 		No 0
BPNT1-202
ENSP00000410348
ENST00000414869
O95861 [Direct mapping]
3'(2'),5'-bisphosphate nucleotidase 1
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000287 [magnesium ion binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006139 [nucleobase-containing compound metabolic process]
GO:0006805 [xenobiotic metabolic process]
GO:0007399 [nervous system development]
GO:0008441 [3'(2'),5'-bisphosphate nucleotidase activity]
GO:0016311 [dephosphorylation]
GO:0044281 [small molecule metabolic process]
GO:0046854 [phosphatidylinositol phosphorylation]
GO:0050427 [3'-phosphoadenosine 5'-phosphosulfate metabolic process]
GO:0070062 [extracellular exosome]
Show all
 272 aa
29.2 kDa 		No 0
BPNT1-203
ENSP00000444398
ENST00000544404
O95861 [Direct mapping]
3'(2'),5'-bisphosphate nucleotidase 1
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000287 [magnesium ion binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006139 [nucleobase-containing compound metabolic process]
GO:0006805 [xenobiotic metabolic process]
GO:0007399 [nervous system development]
GO:0008441 [3'(2'),5'-bisphosphate nucleotidase activity]
GO:0016311 [dephosphorylation]
GO:0044281 [small molecule metabolic process]
GO:0046854 [phosphatidylinositol phosphorylation]
GO:0050427 [3'-phosphoadenosine 5'-phosphosulfate metabolic process]
GO:0070062 [extracellular exosome]
Show all
 253 aa
27.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.