Expression of CAPN13 in cancer - Summary - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

CAPN13

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	CAPN13
Gene description	Calpain 13
Protein class	Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	1
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Cell line enhanced (RT4, SK-BR-3, T-47d)
HPA (normal tissue):	Tissue enhanced (rectum, small intestine, stomach)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General cytoplasmic expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Uncertain based on 2 antibodies. HPA029497 , HPA030034
	SHOW MORE

PROGNOSTIC SUMMARY
Gene product is not prognostic.
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA029497	HPA030034

GENE INFORMATION
Gene name	CAPN13 (HGNC Symbol)
Synonyms	FLJ23523
Description	Calpain 13 (HGNC Symbol)
Entrez gene summary	The calpains, calcium-activated neutral proteases, are nonlysosomal, intracellular cysteine proteases. The mammalian calpains include ubiquitous, stomach-specific, and muscle-specific proteins. The ubiquitous enzymes consist of heterodimers with distinct large, catalytic subunits associated with a common small, regulatory subunit. This gene encodes a member of the calpain large subunit family. [provided by RefSeq, Jun 2012]
Chromosome	2
Cytoband	p23.1
Chromosome location (bp)	30722771 - 30820542
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000162949 (version 83.38)
Entrez gene	92291
UniProt	Q6MZZ7 (UniProt - Evidence at protein level)
neXtProt	NX_Q6MZZ7
Antibodypedia	CAPN13 antibodies

PROTEIN BROWSER

CAPN13-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CAPN13-001 ENSP00000295055 ENST00000295055	Q6MZZ7 [Direct mapping] Calpain-13 Show all	Enzymes Peptidases Cysteine-type peptidases Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0004198 [calcium-dependent cysteine-type endopeptidase activity] GO:0005622 [intracellular] GO:0005737 [cytoplasm] GO:0006508 [proteolysis] Show all	669 aa 76.7 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.