Tissue expression of CAPN13 - Summary - The Human Protein Atlas

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CAPN13

TISSUE

CELL

PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	CAPN13
Gene description	Calpain 13
Protein class	Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enhanced (rectum, small intestine, stomach)
GTEx:	Tissue enhanced (small intestine, stomach)
FANTOM5:	Group enriched (colon, pancreas, small intestine)

Protein evidence

Evidence at protein level

Protein expression

General cytoplasmic expression.

DATA RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Uncertain based on 2 antibodies. HPA029497 , HPA030034
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (rectum, small intestine, stomach)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (small intestine, stomach)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Group enriched (colon, pancreas, small intestine)

GENE INFORMATION
Gene name	CAPN13 (HGNC Symbol)
Synonyms	FLJ23523
Description	Calpain 13 (HGNC Symbol)
Entrez gene summary	The calpains, calcium-activated neutral proteases, are nonlysosomal, intracellular cysteine proteases. The mammalian calpains include ubiquitous, stomach-specific, and muscle-specific proteins. The ubiquitous enzymes consist of heterodimers with distinct large, catalytic subunits associated with a common small, regulatory subunit. This gene encodes a member of the calpain large subunit family. [provided by RefSeq, Jun 2012]
Chromosome	2
Cytoband	p23.1
Chromosome location (bp)	30722771 - 30820542
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000162949 (version 83.38)
Entrez gene	92291
UniProt	Q6MZZ7 (UniProt - Evidence at protein level)
neXtProt	NX_Q6MZZ7
Antibodypedia	CAPN13 antibodies

PROTEIN BROWSER

CAPN13-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CAPN13-001 ENSP00000295055 ENST00000295055	Q6MZZ7 [Direct mapping] Calpain-13 Show all	Enzymes Peptidases Cysteine-type peptidases Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0004198 [calcium-dependent cysteine-type endopeptidase activity] GO:0005622 [intracellular] GO:0005737 [cytoplasm] GO:0006508 [proteolysis] Show all	669 aa 76.7 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.